Frequency-dependent signal transmission and modulation by neuromodulators.
Frequency-dependent signal transmission and modulation by neuromodulators.
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DOI:
10.3389/neuro.01.027.2008
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发表时间:
2008-12
影响因子:
4.3
通讯作者:
Schuman EM
中科院分区:
文献类型:
--
作者:
Ito HT;Schuman EM
The brain uses a strategy of labor division, which may allow it to accomplish more elaborate and complicated tasks, but in turn, imposes a requirement for central control to integrate information among different brain areas. Anatomically, the divergence of long-range neuromodulator projections appears well-suited to coordinate communication between brain areas. Oscillatory brain activity is a prominent feature of neural transmission. Thus, the ability of neuromodulators to modulate signal transmission in a frequency-dependent manner adds an additional level of regulation. Here, we review the significance of frequency-dependent signal modulation in brain function and how a neuronal network can possess such properties. We also describe how a neuromodulator, dopamine, changes frequency-dependent signal transmission, controlling information flow from the entorhinal cortex to the hippocampus.
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