Frequency-dependent signal transmission and modulation by neuromodulators.

Frequency-dependent signal transmission and modulation by neuromodulators.
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DOI:
10.3389/neuro.01.027.2008
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发表时间:
2008-12
影响因子:
4.3
通讯作者:
Schuman EM
Schuman EM
中科院分区:
医学2区
文献类型:
--
作者:
Ito HT;Schuman EM

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大脑使用一种分工策略,这可能使它能够完成更精细和复杂的任务,但反过来,又要求中央控制在不同的大脑区域之间整合信息。从解剖学上讲,远距离神经调节剂投射的分化似乎很适合协调大脑区域之间的交流。振荡性脑活动是神经传递的一个显著特征。因此,神经调节剂以频率依赖的方式调节信号传输的能力增加了一个额外的调节水平。在这里,我们回顾了频率相关信号调制在脑功能中的重要性,以及神经元网络如何具有这种特性。我们还描述了神经调节剂多巴胺如何改变频率依赖的信号传输,控制从内嗅皮层到海马体的信息流。
The brain uses a strategy of labor division, which may allow it to accomplish more elaborate and complicated tasks, but in turn, imposes a requirement for central control to integrate information among different brain areas. Anatomically, the divergence of long-range neuromodulator projections appears well-suited to coordinate communication between brain areas. Oscillatory brain activity is a prominent feature of neural transmission. Thus, the ability of neuromodulators to modulate signal transmission in a frequency-dependent manner adds an additional level of regulation. Here, we review the significance of frequency-dependent signal modulation in brain function and how a neuronal network can possess such properties. We also describe how a neuromodulator, dopamine, changes frequency-dependent signal transmission, controlling information flow from the entorhinal cortex to the hippocampus.
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