Transcription factor BES1 interacts with HSFA1 to promote heat stress resistance of plants.
Transcription factor BES1 interacts with HSFA1 to promote heat stress resistance of plants.
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DOI：
10.15252/embj.2021108664
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发表时间：
2022-02-01
期刊：
影响因子：
--
通讯作者：
Poppenberger B
中科院分区：
文献类型：
--
作者：
Albertos P;Dündar G;Schenk P;Carrera S;Cavelius P;Sieberer T;Poppenberger B
热胁迫是限制植物生长发育的一种主要环境胁迫类型。为了在突如其来的气温升高中生存，植物利用了热休克反应，这是一种古老的信号传递途径。初步结果表明，油菜素类固醇(BRs)在这一反应中发挥了作用。油菜素类固醇是一种促进生长的类固醇激素，其活性受BES1/BZR1亚家族转录因子的调节。在这里，我们提供了BES1参与热应激信号转导的证据。作为对热的响应，BES1即使在没有BRS的情况下也被激活，并直接与热休克元件(HSE)结合，热休克转录因子(HSF)的已知结合部位。HSFA1型HSFs可与BES1相互作用，促进其与HSE结合。这些发现导致我们提出了一个植物热应激反应的扩展模型，在该模型中，BES1的招募是热应激信号与中央生长调节途径相互作用的一种手段。油菜素类固醇调节的转录因子BES1在热应激下被激活，而不是油菜素类固醇，与HSFA1热休克因子协同调节热休克蛋白的表达。
Heat stress is a major environmental stress type that can limit plant growth and development. To survive sudden temperature increases, plants utilize the heat shock response, an ancient signaling pathway. Initial results had suggested a role for brassinosteroids (BRs) in this response. Brassinosteroids are growth‐promoting steroid hormones whose activity is mediated by transcription factors of the BES1/BZR1 subfamily. Here, we provide evidence that BES1 can contribute to heat stress signaling. In response to heat, BES1 is activated even in the absence of BRs and directly binds to heat shock elements (HSEs), known binding sites of heat shock transcription factors (HSFs). HSFs of the HSFA1 type can interact with BES1 and facilitate its activity in HSE binding. These findings lead us to propose an extended model of the heat stress response in plants, in which the recruitment of BES1 is a means of heat stress signaling cross‐talk with a central growth regulatory pathway. The brassinosteroid‐regulated transcription factor BES1 is activated by heat stress independently of brassinosteroids to regulate the expression of heat‐shock proteins in collaboration with HSFA1 heat shock factors.
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