Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases.
Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases.
复制标题
DOI：
10.1016/j.chom.2014.09.015
复制
发表时间：
2014-11-12
影响因子：
30.3
通讯作者：
Mekalanos JJ
中科院分区：
文献类型：
--
作者：
Suzuki M;Danilchanka O;Mekalanos JJ
细胞监视激活的解毒和防御（cSADD）理论假设存在宿主监视机制，该机制监测病原体效应物靶向的常见细胞过程和组分的完整性。作为多种细胞过程（包括先天免疫应答）所必需的细胞器，线粒体代表了病原体的有吸引力的靶标。我们描述了一种霍乱弧菌3型分泌系统效应器VopE，其在感染期间定位于线粒体，并通过充当特异性GTP酶激活蛋白来干扰线粒体Rho GTP酶Miro1和Miro2的功能。Miro GTP酶调节线粒体动力学，并且干扰这种功能有效地阻断先天免疫应答，所述先天免疫应答可能需要线粒体作为信号平台。我们的数据表明，干扰线粒体动力学可能是一种不受重视的策略，病原体用来阻止宿主先天免疫反应，否则将控制这些细菌感染。VopE可能代表靶向cSADD监测反应的细菌效应物。
The c ellular surveillance-activated detoxification and defenses (cSADD) theory postulates the presence of host surveillance mechanisms that monitor the integrity of common cellular processes and components targeted by pathogen effectors. Being organelles essential for multiple cellular processes, including innate immune responses, mitochondria represent an attractive target for pathogens. We describe a Vibrio cholerae Type 3 secretion system effector VopE that localizes to mitochondria during infection and interferes with the function of mitochondrial Rho GTPases Miro1 and Miro2 by acting as a specific GTPase-activating protein. Miro GTPases modulate mitochondrial dynamics and interference with this functionality effectively blocks innate immune responses that presumably require mitochondria as signaling platforms. Our data indicate that interference with mitochondrial dynamics may be an unappreciated strategy that pathogens use to block host innate immune responses that would otherwise control these bacterial infections. VopE might represent a bacterial effector that targets the cSADD surveillance response.
登录
查看更多内容
DOI：
10.1083/jcb.200601067
发表时间：
2006-05-22
期刊：
The Journal of cell biology
影响因子：
--
作者：
Glater EE;Megeath LJ;Stowers RS;Schwarz TL
通讯作者：
Schwarz TL
影响因子：
5.4
作者：
Broberg, Christopher A.;Orth, Kim
通讯作者：
Orth, Kim
DOI：
10.1073/pnas.1106862108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Chang, Karen T.;Niescier, Robert F.;Min, Kyung-Tai
通讯作者：
Min, Kyung-Tai
影响因子：
64.5
作者：
Dong, Na;Zhu, Yongqun;Shao, Feng
通讯作者：
Shao, Feng
影响因子：
5.4
作者：
Gack, Michaela U.
通讯作者：
Gack, Michaela U.