Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study.
Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study.
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DOI：
10.1016/j.atherosclerosis.2012.05.030
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发表时间：
2012-12
期刊：
影响因子：
5.3
通讯作者：
Robins, Sander J.
中科院分区：
文献类型：
--
作者：
Harris, William S.;Pottala, James V.;Lacey, Sean M.;Vasan, Ramachandran S.;Larson, Martin G.;Robins, Sander J.
红细胞（RBC）中二十碳五烯酸（EPA）和二十二碳六烯酸（DHA，omega-3指数，以总脂肪酸的百分比表示）的水平与心血管疾病（CVD）的风险呈负相关。虽然已经提出了这种关系的几种机制，但了解社区中omega-3指数和CVD标志物之间的关联可以进一步阐明这个问题。本研究的目的是确定omega-3指数和临床因素之间的关系，并确定omega-3指数的遗传性。通过气相色谱法分析了2005年至2008年期间从Frachial研究[后代队列的检查8加上Omni（少数民族）队列的检查3]参与者中采集的RBC样本（n = 3196）的脂肪酸组成。平均（SD）omega-3指数为5.6%（1.7%）。在多变量回归模型中，与omega-3指数显著和直接相关的因素是年龄、女性、高等教育、鱼油补充剂、EPA + DHA饮食摄入量、阿司匹林使用、脂质药物治疗和LDL-胆固醇。负相关的因素是后代队列，心率，腰围，甘油三酯和吸烟。完全调整模型的omega-3指数的总解释变异性为73%，其中包括遗传性（24%），EPA + DHA摄入量（25%）和鱼油补充剂（15%）的主要成分。omega-3指数的变化主要由饮食和遗传因素决定。增加的omega-3指数与通常的心脏保护风险因素环境相关。
Red blood cell (RBC) levels of eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA, the omega-3 index, expressed as a percent of total fatty acids) are inversely related to risk for cardiovascular disease (CVD). Although several mechanisms underlying this relationship have been proposed, understanding the associations between the omega-3 index and markers of CVD in the community can shed additional light on this question. The objectives of this study were to define the relations between the omega-3 index and clinical factors and to determine the heritability of the omega-3 index. RBC samples (n = 3196) drawn between 2005 and 2008 from participants in the Framingham Study [Examination 8 of the Offspring cohort plus Examination 3 of the Omni (minorities) cohort] were analyzed for fatty acid composition by gas chromatography. The mean (SD) omega-3 index was 5.6% (1.7%). In multivariable regression models, the factors significantly and directly associated with the omega-3 index were age, female sex, higher education, fish oil supplementation, dietary intake of EPA + DHA, aspirin use, lipid pharmacotherapy, and LDL-cholesterol. Factors inversely associated were Offspring cohort, heart rate, waist girth, triglycerides and smoking. The total explained variability in the omega-3 index for the fully adjusted model was 73%, which included major components due to heritability (24%), EPA + DHA intake (25%), and fish oil supplementation (15%). The variability in the omega-3 index is determined primarily by dietary and genetic factors. An increased omega-3 index is associated with a generally cardioprotective risk factor milieu.
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影响因子：
158.5
作者：
Albert, CM;Campos, H;Ma, J
通讯作者：
Ma, J
影响因子：
4.2
作者：
Cohen, Beth E.;Garg, Sachin K.;Whooley, Mary A.
通讯作者：
Whooley, Mary A.
影响因子：
4.7
作者：
Babin, F;Abderrazik, M;Descomps, B
通讯作者：
Descomps, B
DOI：
10.1016/s0952-3278(03)00111-x
发表时间：
2003-10-01
影响因子：
3
作者：
Burdge, GC;Wootton, SA
通讯作者：
Wootton, SA
影响因子：
7.1
作者：
Djousse, Luc;Biggs, Mary L.;Mozaffarian, Dariush
通讯作者：
Mozaffarian, Dariush