Relationship between effortful motivation and neurocognition in schizophrenia.
Relationship between effortful motivation and neurocognition in schizophrenia.
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DOI：
10.1016/j.schres.2017.06.042
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发表时间：
2018-03
影响因子：
4.5
通讯作者：
Light GA
中科院分区：
文献类型：
--
作者：
Bismark AW;Thomas ML;Tarasenko M;Shiluk AL;Rackelmann SY;Young JW;Light GA
精神分裂症（SZ）患者的努力动机和奖励评价学习缺陷与阴性症状和认知受损相关。而动机和奖励价值的临床评估通常依赖于临床医生的评级或自我报告量表，行为措施往往混淆这些结构。简单的反向翻译行为任务，独立量化的动机和奖励的价值，然后可以联系到认知，可能会促进亲认知疗法的发展，通过弥合“临床前到临床”的差距。本研究确定是否新的行为措施的努力动机和奖励价值与SZ患者（n=36）的认知受损。患者完成了渐进比率断点任务（PRBT;体力努力动机）和概率学习任务（PLT;奖励学习/评价），并结合MATRICS共识认知成套测验（MCCB）。SZ患者在整体认知和所有个体MCCB子域中表现出统计学显著性缺陷。PRBT与MCCB整体认知（r=0.52）、加工速度（r=0.56）和注意警觉（r=0.48）子领域显著相关，但与PLT和临床症状无关。结果表明，努力和奖励学习缺陷是可分离的目标，可以提高我们的理解与SZ患者之间的认知障碍。更重要的是，研究结果支持了一个长期存在的观点，即SZ中认知障碍的测量与付出努力的意愿高度相关。设计用于啮齿动物和人类的PRBT的可用性可以提高我们对神经精神疾病中认知障碍性质的理解，并加速新型促认知疗法的开发。
Effortful motivation and reward valuation learning deficits are associated with negative symptoms and impaired cognition in schizophrenia (SZ) patients. Whereas clinical assessments of motivation and reward value typically rely upon clinician ratings or self-report scales, behavioral measures often confound these constructs. Simple reverse-translated behavioral tasks that independently quantify motivation and reward valuation—which could then be linked to cognition—may facilitate the development of pro-cognitive therapeutics by bridging the “preclinical-to-clinical” gap. This study determined whether novel behavioral measures of effortful motivation and reward valuation are associated with impaired cognition in SZ patients (n=36). Patients completed the Progressive Ratio Breakpoint task (PRBT; physical effort motivation) and the Probabilistic Learning Task (PLT; reward learning/valuation) in conjunction with the MATRICS Consensus Cognitive Battery (MCCB). SZ patients exhibited statistically significant deficits in global cognition and all individual MCCB subdomains. Significant correlations were observed between PRBT and MCCB global cognition (r=0.52), speed of processing (r=0.56) and attention vigilance (r=0.48) subdomains, but not with PLT or clinical symptoms. Results indicate that effort and reward learning deficits are dissociable targets that can improve our understanding of cognitive impairments associated among patients with SZ. More importantly, the results support the long-standing notion that the measurement of cognitive impairments in SZ is highly linked to a willingness to expend effort. The availability of a PRBT designed for use in both rodents and humans could improve our understanding of the nature of cognitive impairments in neuropsychiatric disorders and accelerate the development of novel pro-cognitive therapeutics.
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影响因子：
4.3
作者：
Acheson DT;Twamley EW;Young JW
通讯作者：
Young JW
影响因子：
4.5
作者：
Foussias, G.;Siddiqui, I.;Remington, G.
通讯作者：
Remington, G.
影响因子：
3.4
作者：
Heath CJ;Bussey TJ;Saksida LM
通讯作者：
Saksida LM
影响因子：
4.5
作者：
Light, Gregory A.;Swerdlowa, Neal R.;Thomas, Michael L.;Calkins, Monica E.;Green, Michael F.;Greenwood, Tiffany A.;Gur, Raquel E.;Gur, Ruben C.;Lazzeroni, Laura C.;Nuechterlein, Keith H.;Pela, Marlena;Radant, Allen D.;Seidman, Larry J.;Sharp, Richard F.;Siever, Larry J.;Silverman, Jeremy M.;Sprock, Joyce;Stone, William S.;Sugar, Catherine A.;Tsuang, Debby W.;Tsuang, Ming T.;Braff, David L.;Turetsky, Bruce I.
通讯作者：
Turetsky, Bruce I.
DOI：
10.1111/gbb.12268
发表时间：
2016-01
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Cope ZA;Powell SB;Young JW
通讯作者：
Young JW