Transforming Sensory Cues into Aversive Emotion via Septal-Habenular Pathway.
Transforming Sensory Cues into Aversive Emotion via Septal-Habenular Pathway.
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通过隔缰通路将感觉线索转化为厌恶情绪。
DOI：
10.1016/j.neuron.2018.07.023
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发表时间：
2018-09-05
期刊：
影响因子：
16.2
通讯作者：
Tao HW
中科院分区：
文献类型：
--
作者：
Zhang GW;Shen L;Zhong W;Xiong Y;Zhang LI;Tao HW
环境暗示引发的情绪对于动物的生存和生活质量非常重要。然而，负责将感觉信号转化为厌恶情绪和行为回避的神经回路仍不清楚。在这里，我们发现内侧隔膜（MS）介导听觉和体感刺激引起的厌恶。谷氨酸能或 GABA 能 MS 神经元的消融分别导致厌恶感受损或增强。两种细胞类型的光遗传学激活分别导致位置回避和偏好。细胞类型特异性筛选表明，谷氨酸能 MS 投射到外侧缰核 (LHb) 负责诱导厌恶，而 GABA 能 MS 投射到 LHb 可以拮抗这种厌恶感。此外，由谷氨酸能 MS 投射到视前区介导的增强运动促进了感觉诱导的位置回避。因此，MS可以通过自下而上的多模态感觉通路传递固有的厌恶信号，并产生并发的情绪和运动效应，使动物能够有效地避开不利的环境。张等人。揭示了一个处理先天厌恶的感觉信号的电路，通过从 MS 到 LHb 和 POA 的谷氨酸能投射，分别产生情绪和运动效果。 MS 在调节厌恶方面的作用以前未被认识到。
Emotions evoked by environmental cues are important for animal survival and life quality. However, neural circuits responsible for transforming sensory signals to aversive emotion and behavioral avoidance remain unclear. Here, we found that medial septum (MS) mediates aversion induced by both auditory and somatosensory stimuli. Ablation of glutamatergic or GABAergic MS neurons results in impaired or strengthened aversion respectively. Optogenetic activation of the two cell types results in place-avoidance and -preference, respectively. Cell-type specific screening reveals that glutamatergic MS projections to the lateral habenula (LHb) are responsible for the induction of aversion, which can be antagonized by GABAergic MS projections to LHb. Additionally, the sensory induced place avoidance is facilitated by enhanced locomotion, mediated by glutamatergic MS projections to the preoptic area. Thus, MS can transmit innately aversive signals via a bottom-up multimodal sensory pathway and produce concurrent emotional and motional effects, allowing animals to efficiently avoid unfavorable environments. Zhang et al. revealed a circuit for processing innately aversive sensory signals, with glutamatergic projections from MS to LHb and POA to generate the emotional and a motional effect, respectively. This role of MS in mediating aversion is previously unrecognized.
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