Mapping resting-state brain networks in conscious animals.
Mapping resting-state brain networks in conscious animals.
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DOI：
10.1016/j.jneumeth.2010.04.001
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发表时间：
2010-06-15
影响因子：
3
通讯作者：
King, Jean
中科院分区：
文献类型：
--
作者：
Zhang, Nanyin;Rane, Pallavi;Huang, Wei;Liang, Zhifeng;Kennedy, David;Frazier, Jean A.;King, Jean
关键词：
在本研究中，我们基于内在血氧水平依赖（BOLD）波动绘制了有意识大鼠在“静息状态”下的脑功能连通性。清醒状态消除了麻醉剂对脑区连接的潜在混淆效应。事实上，通过相关分析，我们发现了多个皮层和皮层下区域，这些区域在时间上与解剖学上明确定义的区域同步变化，这些区域对认知和情感信息处理至关重要，包括前额叶皮层（PFC）、丘脑和脾后皮层。通过控制相关的假阳性检测，信号源的生理基础，以及定量评估图的可重复性，严格验证了所创建的功能连接图。综上所述，本研究证明了使用功能磁共振成像评估有意识动物功能连接的可行性，从而为系统研究多种动物模型中选定脑网络的连接结构提供了一种方便且无创的工具。
In the present study we mapped brain functional connectivity in the conscious rat at the “resting state” based on intrinsic blood-oxygenation-level dependent (BOLD) fluctuations. The conscious condition eliminated potential confounding effects of anesthetic agents on the connectivity between brain regions. Indeed, using correlational analysis we identified multiple cortical and subcortical regions that demonstrated temporally synchronous variation with anatomically well-defined regions that are crucial to cognitive and emotional information processing including the prefrontal cortex (PFC), thalamus and retrosplenial cortex. The functional connectivity maps created were stringently validated by controlling for false positive detection of correlation, the physiologic basis of the signal source, as well as quantitatively evaluating the reproducibility of maps. Taken together, the present study has demonstrated the feasibility of assessing functional connectivity in conscious animals using fMRI and thus provided a convenient and non-invasive tool to systematically investigate the connectional architecture of selected brain networks in multiple animal models.
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影响因子：
19.9
作者：
Epstein, Russell A.
通讯作者：
Epstein, Russell A.
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1016/j.cub.2009.04.028
发表时间：
2009-06-23
期刊：
Current biology : CB
影响因子：
--
作者：
Albert NB;Robertson EM;Miall RC
通讯作者：
Miall RC
影响因子：
2.5
作者：
AGGLETON, JP;DESIMONE, R;MISHKIN, M
通讯作者：
MISHKIN, M
影响因子：
56.9
作者：
DAMASIO, H;GRABOWSKI, T;DAMASIO, AR
通讯作者：
DAMASIO, AR