Functional neurogenesis over the years.
Functional neurogenesis over the years.
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DOI：
10.1016/j.bbr.2020.112470
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发表时间：
2020-03-16
影响因子：
2.7
通讯作者：
Drew MR
中科院分区：
文献类型：
--
作者：
Snyder JS;Drew MR
自从约瑟夫·奥特曼（Joseph Altman）在近60年前发现成人神经发生的功能以来，人们一直对它感兴趣。尽管争议减少了后续研究，但在20世纪90年代，第二波研究证实了奥特曼最初的许多说法，并揭示了压力和环境刺激等因素会改变海马体中新神经元的产生。然而，只有随着操纵神经发生的工具的出现，才有可能对新生神经元的功能进行因果测试。在这里，我们确定了大约100项研究，其中成人神经发生被操纵来研究其功能。这些研究大多证明了成人神经发生在经典海马行为中的功能，如情境学习和空间记忆，以及与压力、焦虑和抑郁相关的情绪行为。然而，仔细观察就会发现，在决策、时间关联记忆和成瘾等方面，大脑还有其他一些可能尚未得到充分研究的功能。在这期特刊中，我们介绍了16项新的研究和综述文章，继续讨论和阐明成人神经发生在多种行为中的功能，如记忆形成和巩固、模式分离和区分行为、成瘾和注意。对干细胞动力学和再生特性的回顾提供了对神经发生可能被控制以抵消年龄和疾病相关脑损伤的机制的见解。最后，以翻译为导向的审查确定了今后的步骤，以尽量减少动物发现与人类健康应用之间的差距。本期的文章综合并扩展了我们在过去半个世纪的功能性神经发生研究中所学到的知识，并确定了将定义其未来的主题。
There has been interest in the function of adult neurogenesis since its discovery, by Joseph Altman, nearly 60 years ago. While controversy curtailed follow up studies, in the 1990s a second wave of research validated many of Altman’s original claims and revealed that factors such as stress and environmental stimulation altered the production of new neurons in the hippocampus. However, only with the advent of tools for manipulating neurogenesis did it become possible to perform causal tests of the function of newborn neurons. Here, we identify approximately 100 studies in which adult neurogenesis was manipulated to study its function. A majority of these studies demonstrate functions for adult neurogenesis in classic hippocampal behaviors such as context learning and spatial memory, as well as emotional behaviors related to stress, anxiety and depression. However, a closer look reveals a number of other, arguably understudied, functions in decision making, temporal association memory, and addiction. In this special issue, we present 16 new studies and review articles that continue to address and clarify the function of adult neurogenesis in behaviors as diverse as memory formation and consolidation, pattern separation and discrimination behaviors, addiction, and attention. Reviews of stem cell dynamics and regenerative properties provide insights into the mechanisms by which neurogenesis may be controlled to offset age- and disease-related brain injury. Finally, translation-oriented reviews identify next steps for minimizing the gap between discoveries made in animals and applications for human health. The articles in this issue synthesize and extend what we have learned in the last half century of functional neurogenesis research and identify themes that will define its future.
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影响因子：
3.5
作者：
Bekinschtein, Pedro;Kent, Brianne A.;Oomen, Charlotte A.;Clemenson, Gregory D.;Gage, Fred H.;Saksida, Lisa M.;Bussey, Timothy J.
通讯作者：
Bussey, Timothy J.
影响因子：
2.9
作者：
CAMERON, HA;WOOLLEY, CS;GOULD, E
通讯作者：
GOULD, E
DOI：
10.1073/pnas.120552597
发表时间：
2000-06-20
影响因子：
11.1
作者：
Eisch, AJ;Barrot, M;Nestler, EJ
通讯作者：
Nestler, EJ
影响因子：
2.7
作者：
Ben Abdallah, Nada M. -B.;Filipkowski, Robert K.;Lipp, Hans-Peter
通讯作者：
Lipp, Hans-Peter
影响因子：
5
作者：
Dennis CV;Suh LS;Rodriguez ML;Kril JJ;Sutherland GT
通讯作者：
Sutherland GT