Children's inferential styles, 5-HTTLPR genotype, and maternal expressed emotion-criticism: An integrated model for the intergenerational transmission of depression.
Children's inferential styles, 5-HTTLPR genotype, and maternal expressed emotion-criticism: An integrated model for the intergenerational transmission of depression.
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DOI：
10.1037/a0016765
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发表时间：
2009-11
影响因子：
4.6
通讯作者：
McGeary, John
中科院分区：
文献类型：
--
作者：
Gibb, Brandon E.;Uhrlass, Dorothy J.;Grassia, Marie;Benas, Jessica S.;McGeary, John
我们测试了一个抑郁症代际传播模型，该模型整合了特定的遗传（5-HTTLPR）、认知（推理风格）和环境（母亲抑郁症状和表达情绪批评）风险因素。支持这一假设，即母亲抑郁症与儿童生活中的压力水平升高有关，有重度抑郁症（MDD）病史的母亲在6个月的多波随访中表现出比无抑郁症病史的母亲更高的抑郁症状。此外，部分支持我们的假设，母亲的批评水平在随访期间显着相关的母亲目前的抑郁症状，但没有抑郁症的历史。最后，我们发现了一个综合的基因×认知×环境风险模型的支持。具体而言，在自我特征方面具有消极推理风格的儿童中，5-HTTLPR基因型存在明显的剂量反应，调节了母亲批评与儿童抑郁症状之间的关系，在随访期间，在携带两个5-HTTLPR低表达等位基因（S或LG）拷贝的儿童中观察到最严重的抑郁症状，这些儿童也表现出对自我的消极推理风格，相比之下，具有积极推理风格的儿童表现出较低的抑郁症状，无论5-HTTLPR基因型或母亲批评水平如何。
We tested a model for the intergenerational transmission of depression integrating specific genetic (5-HTTLPR), cognitive (inferential style), and environmental (mother depressive symptoms and expressed-emotion criticism) risk factors. Supporting the hypothesis that maternal depression is associated with elevated levels of stress in children’s lives, mothers with a history of major depressive disorder (MDD) exhibited higher depressive symptoms across a 6-month multi-wave follow-up than mothers with no depression history. In addition, partially supporting our hypothesis, levels of maternal criticism during the follow-up were significantly related to mothers’ current depressive symptoms, but not history of MDD. Finally, we found support for an integrated gene × cognition × environment model of risk. Specifically, among children with negative inferential styles regarding their self-characteristics, there was a clear dose response of 5-HTTLPR genotype moderating the relation between maternal criticism and children’s depressive symptoms, with the highest depressive symptoms during the follow-up observed among children carrying two copies of the 5-HTTLPR lower expressing alleles (S or LG) who also exhibited negative inferential styles for self-characteristics and who experienced high levels of EE-Crit. In contrast, children with positive inferential styles exhibited low depressive symptoms regardless of 5-HTTLPR genotype or level of maternal criticism.
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DOI：
10.1080/15374410902851705
发表时间：
2009-05
期刊：
Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
影响因子：
--
作者：
Gibb BE;Benas JS;Grassia M;McGeary J
通讯作者：
McGeary J
DOI：
10.1207/s15374424jccp3502_9
发表时间：
2006-06-01
影响因子：
4.2
作者：
Abela, JRZ;Skitch, SA;Hankin, BL
通讯作者：
Hankin, BL
影响因子：
2.8
作者：
Abela, JRZ;Payne, AVL
通讯作者：
Payne, AVL
影响因子：
4.1
作者：
Firk, Christine;Markus, C. Rob
通讯作者：
Markus, C. Rob
DOI：
10.1097/00004583-199411000-00007
发表时间：
1994-11-01
影响因子：
13.3
作者：
GOODMAN, SH;ADAMSON, LB;COLE, S
通讯作者：
COLE, S