Mortality and cancer incidence in UK military veterans involved in human experiments at Porton Down: 48-year follow-up.
Mortality and cancer incidence in UK military veterans involved in human experiments at Porton Down: 48-year follow-up.
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DOI：
10.1093/ije/dyad050
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发表时间：
2023-08-02
影响因子：
7.7
通讯作者：
中科院分区：
文献类型：
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我们调查了在Porton Down从事化学战剂研究的军事人员是否增加了死亡率或癌症发病率。这是一项历史队列研究，包括男性英国退伍军人谁参加了“服务志愿者计划”，1941年至1989年，确定从波顿唐实验书籍，和一个类似的“非波顿唐”退伍军人从军事人员档案确定的比较组。在每组检索到的19233条记录中，18133条（94%）Porton Down和17591条（92%）非Porton Down被纳入我们的分析样本。 截至2019年12月，死亡率和癌症发病率数据来自国家登记处。在平均48.1年的随访中，10935名Porton Down退伍军人（60.3%）和10658名非Porton Down退伍军人（60.6%）死亡。 在调整年龄、出生年份和兵役特征后，总体而言，与非Porton Down退伍军人相比，Porton Down退伍军人的全因死亡率高出6%[风险比（HR）= 1.06，95%置信区间（CI）1.03-1.09]。对于死因特异性死亡率，Porton Down退伍军人死于泌尿生殖系统疾病的比率较高（HR = 1.34，95% CI 1.05-1.70）和酒精所致死亡（HR = 1.44，95% CI 1.07-1.94），观察到与传染病和寄生虫病死亡的相关性较弱（HR = 1.32，95% CI 0.99-1.78）、肺癌（HR = 1.10，95% CI 1.01-1.20）和外部原因（HR = 1.15，95% CI 1.00-1.32）。在1960年至1964年期间参加Porton Down的退伍军人与全因死亡率的相关性更强（HR = 1.34，95%CI 1.19-1.50）;似然比检验，P = 0.006。在Porton Down就诊与总体癌症发病率之间没有关联（HR = 1.00，95% CI 0.95-1.03）。总的来说，Porton Down退伍军人的死亡率略高，但癌症发病率没有差异。在20世纪60年代初参加的波顿唐退伍军人中，死亡率的相关性更强。
We investigated whether military personnel involved in chemical warfare agent research at Porton Down had increased rates of mortality or cancer incidence. This was a historical cohort study comprising male UK veterans who participated in the ‘Service Volunteer Programme’, 1941–89, identified from Porton Down experiment books, and a comparison group of similar ‘non-Porton Down’ veterans identified from military personnel files. Of 19 233 records retrieved for each group, 18 133 (94%) Porton Down and 17 591 (92%) non-Porton Down were included in our analytical sample. Mortality and cancer incidence data were obtained from national registries up to December 2019. Over a median follow-up of 48.1 years, 10 935 Porton Down veterans (60.3%) and 10 658 non-Porton Down veterans (60.6%) had died. After adjustment for age, year of birth and military service characteristics, overall, Porton Down veterans had a 6% higher rate of all-cause mortality compared with non-Porton Down veterans [hazard ratio (HR) = 1.06, 95% confidence interval (CI) 1.03–1.09]. For cause-specific mortality, Porton Down veterans had higher rates of death from genitourinary diseases (HR = 1.34, 95% CI 1.05–1.70) and deaths attributable to alcohol (HR = 1.44, 95% CI 1.07–1.94), with weaker associations observed for deaths from infectious and parasitic diseases (HR = 1.32, 95% CI 0.99–1.78), lung cancer (HR = 1.10, 95% CI 1.01–1.20) and external causes (HR = 1.15, 95% CI 1.00–1.32). Associations with all-cause mortality were stronger for veterans who attended Porton Down between 1960 and 1964 (HR = 1.34, 95% CI 1.19–1.50); likelihood-ratio test, P = 0.006. There was no association between attendance at Porton Down and overall cancer incidence (HR = 1.00, 95% CI 0.95–1.03). Overall, mortality rates were slightly higher in Porton Down veterans, but there was no difference in cancer incidence. Associations for mortality were stronger in Porton Down veterans who attended in the early 1960s.
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影响因子：
5.6
作者：
Bullman, T;Kang, H
通讯作者：
Kang, H
DOI：
10.1136/bmj.b655
发表时间：
2009-03-24
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Carpenter LM;Linsell L;Brooks C;Keegan TJ;Langdon T;Doyle P;Maconochie NE;Fletcher T;Nieuwenhuijsen MJ;Beral V;Venables KM
通讯作者：
Venables KM
影响因子：
1.2
作者：
Brown, Mark
通讯作者：
Brown, Mark
影响因子：
7.7
作者：
通讯作者：
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影响因子：
5.1
作者：
Poortinga, Wouter
通讯作者：
Poortinga, Wouter