Mediating effect of amygdala activity on response to fear vs. happiness in youth with significant levels of irritability and disruptive mood and behavior disorders.
Mediating effect of amygdala activity on response to fear vs. happiness in youth with significant levels of irritability and disruptive mood and behavior disorders.
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DOI：
10.3389/fnbeh.2023.1204574
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发表时间：
2023
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
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易怒，以表现出愤怒的倾向为特征，是年轻人常见的临床问题。易怒是青少年中一个重要的临床问题，患有各种精神疾病，特别是破坏性行为和情绪障碍(注意力缺陷/多动障碍、对立违抗障碍、品行障碍和破坏性情绪调节障碍)。虽然以前的研究集中在杏仁核中与应激性相关的功能改变，但在情绪、神经元和行为特征之间还没有全面的模型。使用功能磁共振成像(FMRI)程序，我们调查了行为应激性、面部情绪处理的选择性障碍和易怒增加的青少年杏仁核神经反应之间的关系。59名患有破坏性情绪和行为障碍的青少年完成了一项使用事件相关功能磁共振范式的面部表情处理任务。使用情感反应指数评估应激性的严重程度。在行为数据的结果中，解释消极(恐惧)和积极(快乐)面部表情的易怒和反应时(RT)的差异呈正相关。在fMRI结果中，与恐惧状态相比，在快乐状态下，青年在右侧扣带回、双侧小脑、右侧杏仁核、右侧楔前叶、右侧额上回、右侧枕中回和颞中回表现出更高的激活程度。没有一个大脑区域在恐惧中表现出比在快乐状态下更活跃的状态。在中介分析的结果中，易怒程度的增加与正面面部表情比负面面部表情的反应时间更长有关。易怒也与两种情绪状态(快乐和恐惧)之间杏仁核血氧水平依赖反应的差异呈正相关。杏仁核活动的这种差异介导了易怒与正反两种面部表情之间的RT差异之间的相互作用。我们认为，不同价态的面部情绪表达的内隐加工障碍会导致杏仁核反应的不同模式，这与易怒程度有关。这些结果拓宽了我们在神经水平上对易怒的生物学机制的理解，并为未来的研究方向提供了信息。
Irritability, characterized by a tendency to exhibit increased anger, is a common clinical problem in youth. Irritability is a significant clinical issue in youth with various psychiatric diagnoses, especially disruptive behavior, and mood disorders (Attention-Deficit/Hyperactivity Disorder, Oppositional Defiant Disorder, Conduct Disorder, and Disruptive Mood Dysregulation Disorder). Although there have been previous studies focusing on functional alteration in the amygdala related to irritability, there is no comprehensive model between emotional, neuronal, and behavioral characteristics. Using an functional magnetic resonance imaging (fMRI) procedure, we investigated the relationships between behavioral irritability, selective impairments in processing facial emotions and the amygdala neural response in youth with increased irritability. Fifty-nine youth with disruptive mood and behavior disorder completed a facial expression processing task with an event-related fMRI paradigm. The severity of irritability was evaluated using the Affective Reactivity Index. In the result of behavioral data, irritability, and reaction time (RT) differences between interpreting negative (fear) and positive (happiness) facial expressions were positively correlated. In the fMRI result, youth showed higher activation in the right cingulate gyrus, bilateral cerebellum, right amygdala, right precuneus, right superior frontal gyrus, right middle occipital gyrus, and middle temporal gyrus, during the happiness condition vs. fear condition. No brain region exhibited greater activation in the fear than in the happiness conditions. In the result of the mediator analysis, increased irritability was associated with a longer RT toward positive vs. negative facial expressions. Irritability was also positively associated with the difference in amygdala blood oxygen level-dependent responses between the two emotional conditions (happiness > fear). This difference in amygdala activity mediated the interaction between irritability and the RT difference between negative and positive facial expressions. We suggest that impairment in the implicit processing of facial emotional expressions with different valences causes distinct patterns of amygdala response, which correlate with the level of irritability. These results broaden our understanding of the biological mechanism of irritability at the neural level and provide information for the future direction of the study.
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影响因子：
4.2
作者：
Thomas, Laura A.;Kim, Pilyoung;Bones, Brian L.;Hinton, Kendra E.;Milch, Hannah S.;Reynolds, Richard C.;Adleman, Nancy E.;Marsh, Abigail A.;Blair, R. J. R.;Pine, Daniel S.;Leibenluft, Ellen
通讯作者：
Leibenluft, Ellen
影响因子：
4.6
作者：
Framorando D;Moses E;Legrand L;Seeck M;Pegna AJ
通讯作者：
Pegna AJ
影响因子：
5.7
作者：
Fishburn FA;Hlutkowsky CO;Bemis LM;Huppert TJ;Wakschlag LS;Perlman SB
通讯作者：
Perlman SB
影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.1016/j.jaac.2021.05.022
发表时间：
2022-01
影响因子：
13.3
作者：
Haller SP;Stoddard J;Botz-Zapp C;Clayton M;MacGillivray C;Perhamus G;Stiles K;Kircanski K;Penton-Voak IS;Bar-Haim Y;Munafò M;Towbin KE;Brotman MA
通讯作者：
Brotman MA