A Randomized Controlled Trial of Computerized Interpretation Bias Training for Disruptive Mood Dysregulation Disorder: A Fast-Fail Study.
A Randomized Controlled Trial of Computerized Interpretation Bias Training for Disruptive Mood Dysregulation Disorder: A Fast-Fail Study.
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DOI：
10.1016/j.jaac.2021.05.022
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发表时间：
2022-01
影响因子：
13.3
通讯作者：
Brotman MA
中科院分区：
文献类型：
--
作者：
Haller SP;Stoddard J;Botz-Zapp C;Clayton M;MacGillivray C;Perhamus G;Stiles K;Kircanski K;Penton-Voak IS;Bar-Haim Y;Munafò M;Towbin KE;Brotman MA
探索有针对性的、基于机制的干预措施是下一代治疗创新。对模糊的面部情绪进行有偏见的威胁标签（解释偏见）是愤怒、攻击性和烦躁的潜在行为治疗目标。改变面部情绪标签的偏见可能会改善与烦躁相关的结果。在这里，我们报告了第一个针对慢性、严重烦躁青少年的解释偏差训练 (IBT) 的随机、双盲、安慰剂对照靶向试验 (RCT)。当前患有破坏性情绪失调障碍（DMDD；N = 44）的患者被随机分配在一周内完成四节主动（n = 22）或假（n = 22）计算机化IBT训练。第一次和最后一次培训在现场完成，两次培训在家里完成。我们研究了主动 IBT 对标签偏差、易怒的主要结果测量以及焦虑、抑郁和功能障碍的次要结果测量的影响。干预后立即和干预后两周完成随访评估。我们发现，相对于假条件，主动 IBT 使行为目标处于主动状态，这表现为将模糊的面孔标记为快乐的显着转变。然而，在主要或次要结果指标训练后立即或两周后，相对于假手术条件，主动 IBT 没有一致的临床改善。虽然这项针对 DMDD 青少年的 IBT 随机对照试验涉及拟议的行为目标，但临床结果没有统计学上的显着改善。识别和改变行为目标是新疗法开发的第一步；这些结果对有针对性的干预措施的制定具有更广泛的影响。对患有严重烦躁的青少年进行心理治疗； https://clinicaltrials.gov/； NCT02531893。
Probing targeted, mechanism-based interventions is the next generation of treatment innovation. Biased threat labeling of ambiguous face emotions (interpretation bias) is a potential behavioral treatment target for anger, aggression, and irritability. Changing biases in face-emotion labeling may improve irritability-related outcomes. Here, we report the first randomized, double-blind, placebo-controlled targeted trial (RCT) of interpretation bias training (IBT) in youth with chronic, severe irritability. Patients with current Disruptive Mood Dysregulation Disorder (DMDD; N=44) were randomly assigned to complete four sessions of active (n=22) or sham (n=22) computerized IBT training within a one-week period. The first and last trainings were completed onsite, and two trainings were completed at home. We examined the effects of active IBT on labeling bias, primary outcome measures of irritability, and secondary outcome measures of anxiety, depression, and functional impairment. Follow-up assessments were completed immediately after the intervention and two weeks following the intervention. We found that active IBT engaged the behavioral target in the active relative to the sham condition, shown by a significant shift toward labeling ambiguous faces as happy. However, there was no consistent clinical improvement in active IBT relative to the sham condition, immediately after, or two weeks following training in either primary or secondary outcome measures. While this RCT of IBT in youth with DMDD engaged the proposed behavioral target, there was no statistically significant improvement on clinical outcome. Identifying and changing behavioral targets is a first step in novel treatment development; these results have broader implications for targeted-based intervention development. Psychological Treatments for Youth With Severe Irritability; https://clinicaltrials.gov/; NCT02531893.
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DOI：
10.1080/15374416.2017.1310044
发表时间：
2017-01-01
影响因子：
4.2
作者：
Kaminski, Jennifer W.;Claussen, Angelika H.
通讯作者：
Claussen, Angelika H.
影响因子：
17.1
作者：
Hyman, Steven E.
通讯作者：
Hyman, Steven E.
影响因子：
11
作者：
Insel, TR;Scolnick, EM
通讯作者：
Scolnick, EM
影响因子：
4.6
作者：
Crick, NR;Dodge, KA
通讯作者：
Dodge, KA
影响因子：
22.4
作者：
Hallion, Lauren S.;Ruscio, Ayelet Meron
通讯作者：
Ruscio, Ayelet Meron