A standard calculation methodology for human doubly labeled water studies.

A standard calculation methodology for human doubly labeled water studies.
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DOI:
10.1016/j.xcrm.2021.100203
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发表时间:
2021-02-16
期刊:
Cell reports. Medicine
影响因子:
--
通讯作者:
IAEA DLW database group
IAEA DLW database group
中科院分区:
其他
文献类型:
--
作者:
Speakman JR;Yamada Y;Sagayama H;Berman ESF;Ainslie PN;Andersen LF;Anderson LJ;Arab L;Baddou I;Bedu-Addo K;Blaak EE;Blanc S;Bonomi AG;Bouten CVC;Bovet P;Buchowski MS;Butte NF;Camps SGJA;Close GL;Cooper JA;Creasy SA;Das SK;Cooper R;Dugas LR;Ebbeling CB;Ekelund U;Entringer S;Forrester T;Fudge BW;Goris AH;Gurven M;Hambly C;El Hamdouchi A;Hoos MB;Hu S;Joonas N;Joosen AM;Katzmarzyk P;Kempen KP;Kimura M;Kraus WE;Kushner RF;Lambert EV;Leonard WR;Lessan N;Ludwig DS;Martin CK;Medin AC;Meijer EP;Morehen JC;Morton JP;Neuhouser ML;Nicklas TA;Ojiambo RM;Pietiläinen KH;Pitsiladis YP;Plange-Rhule J;Plasqui G;Prentice RL;Rabinovich RA;Racette SB;Raichlen DA;Ravussin E;Reynolds RM;Roberts SB;Schuit AJ;Sjödin AM;Stice E;Urlacher SS;Valenti G;Van Etten LM;Van Mil EA;Wells JCK;Wilson G;Wood BM;Yanovski J;Yoshida T;Zhang X;Murphy-Alford AJ;Loechl CU;Melanson EL;Luke AH;Pontzer H;Rood J;Schoeller DA;Westerterp KR;Wong WW;IAEA DLW database group

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双标记水(DLW)方法测量自由生活受试者的总能量消耗(TEE)。使用几个公式将同位素数据转换为TEE。利用国际原子能机构(原子能机构)DLW数据库(5,756个成人和儿童的测量数据),我们发现,不同的方程引入了相当大的变异性。估算的rCO2对两种同位素的稀释空间比(DSR)很敏感。基于验证研究中的性能,我们提出了一个基于平均DSR的新估计的新方程。低体重(<10千克)的DSR较低。使用1,021名婴儿和婴儿的数据,我们表明DSR随体重在0到10公斤之间呈非线性变化。使用这个关系从体重预测DSR提供了一个在这个尺寸范围内的rCO2公式,它与间接量热法非常吻合(平均差异0.64%;SD=12.2%)。我们建议在未来的研究中采用这些方程。5,756个双标记水(DLW)的测量突出了计算公式的差异我们在这里推导了使用DLW时计算二氧化碳产生的新公式这些公式在验证研究中优于以前的公式我们建议在未来使用DLW在人类中进行研究时采用这些公式。使用一个双标记水量测量的大型数据库来显示能源消耗计算公式的选择给最终估计带来了显着的变化。然后,他们推导出新的方程式,这些方程式在室内量热法的验证研究中表现优于以前的方程式。
The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies. 5,756 doubly labeled water (DLW) measures highlight variation from calculation equation We derive here new equations for calculating CO2 production when using DLW These equations outperform previous equations in validation studies We recommend these equations should be adopted in future studies using DLW in humans Speakman et al. use a large database of doubly labeled water measurements to show the choice of equation for the calculation of energy expenditure introduces significant variation into the final estimate. They then derive new equations that outperform previous equations in validation studies against chamber calorimetry.
DOI: 10.1159/000243391
发表时间: 1991-08-01
期刊: BIOLOGY OF THE NEONATE
影响因子: --
作者:
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DOI: 10.1152/ajpregu.1992.263.3.r685
发表时间: 1992-09-01
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发表时间: 2019-12-01
影响因子: 3.9
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DOI: 10.1152/ajpendo.1991.261.3.e402
发表时间: 1991-09-01
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