A standard calculation methodology for human doubly labeled water studies.
A standard calculation methodology for human doubly labeled water studies.
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DOI:
10.1016/j.xcrm.2021.100203
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发表时间:
2021-02-16
期刊:
影响因子:
--
通讯作者:
IAEA DLW database group
中科院分区:
文献类型:
--
作者:
Speakman JR;Yamada Y;Sagayama H;Berman ESF;Ainslie PN;Andersen LF;Anderson LJ;Arab L;Baddou I;Bedu-Addo K;Blaak EE;Blanc S;Bonomi AG;Bouten CVC;Bovet P;Buchowski MS;Butte NF;Camps SGJA;Close GL;Cooper JA;Creasy SA;Das SK;Cooper R;Dugas LR;Ebbeling CB;Ekelund U;Entringer S;Forrester T;Fudge BW;Goris AH;Gurven M;Hambly C;El Hamdouchi A;Hoos MB;Hu S;Joonas N;Joosen AM;Katzmarzyk P;Kempen KP;Kimura M;Kraus WE;Kushner RF;Lambert EV;Leonard WR;Lessan N;Ludwig DS;Martin CK;Medin AC;Meijer EP;Morehen JC;Morton JP;Neuhouser ML;Nicklas TA;Ojiambo RM;Pietiläinen KH;Pitsiladis YP;Plange-Rhule J;Plasqui G;Prentice RL;Rabinovich RA;Racette SB;Raichlen DA;Ravussin E;Reynolds RM;Roberts SB;Schuit AJ;Sjödin AM;Stice E;Urlacher SS;Valenti G;Van Etten LM;Van Mil EA;Wells JCK;Wilson G;Wood BM;Yanovski J;Yoshida T;Zhang X;Murphy-Alford AJ;Loechl CU;Melanson EL;Luke AH;Pontzer H;Rood J;Schoeller DA;Westerterp KR;Wong WW;IAEA DLW database group
The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies. 5,756 doubly labeled water (DLW) measures highlight variation from calculation equation We derive here new equations for calculating CO2 production when using DLW These equations outperform previous equations in validation studies We recommend these equations should be adopted in future studies using DLW in humans Speakman et al. use a large database of doubly labeled water measurements to show the choice of equation for the calculation of energy expenditure introduces significant variation into the final estimate. They then derive new equations that outperform previous equations in validation studies against chamber calorimetry.
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DOI:
10.1159/000243391
发表时间:
1991-08-01
期刊:
BIOLOGY OF THE NEONATE
影响因子:
--
作者:
WESTERTERP, KR;LAFEBER, HN;SAUER, PJJ
通讯作者:
SAUER, PJJ
影响因子:
--
作者:
JENSEN, CL;BUTTE, NF;MOON, JK
通讯作者:
MOON, JK
DOI:
10.1152/ajpendo.00241.2017
发表时间:
2018-02-01
影响因子:
5.1
作者:
Melanson, Edward L.;Swibas, Tracy;Berman, Elena S. F.
通讯作者:
Berman, Elena S. F.
影响因子:
3.9
作者:
Speakman, John R.;Pontzer, Herman;Murphy-Alford, Alexia J.
通讯作者:
Murphy-Alford, Alexia J.
影响因子:
--
作者:
RAVUSSIN, E;HARPER, IT;BOGARDUS, C
通讯作者:
BOGARDUS, C