Varenicline, a partial agonist at neuronal nicotinic acetylcholine receptors, reduces nicotine-induced increases in 20% ethanol operant self-administration in Sprague-Dawley rats.
Varenicline, a partial agonist at neuronal nicotinic acetylcholine receptors, reduces nicotine-induced increases in 20% ethanol operant self-administration in Sprague-Dawley rats.
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DOI：
10.1111/j.1369-1600.2010.00309.x
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发表时间：
2011-07
影响因子：
3.4
通讯作者：
Bartlett SE
中科院分区：
文献类型：
--
作者：
Bito-Onon JJ;Simms JA;Chatterjee S;Holgate J;Bartlett SE
酒精和尼古丁使用障碍通常被视为不同的疾病，尽管有证据表明，大约80-90%的酒精依赖者同时也是重度吸烟者。尼古丁和乙醇都与神经元尼古丁乙酰胆碱受体（nachr）相互作用，表明这些受体是大脑中尼古丁和乙醇作用的共同生物靶点。很少有研究检查尼古丁和乙醇共同施用对啮齿动物nachr活性的影响。在目前的研究中，我们发现Sprague-Dawley大鼠（一种经常用于尼古丁研究但不经常用于自愿酒精摄入研究的品种）将在不需要蔗糖褪色的情况下使用间歇性获取两瓶选择和操作性自我给药模型消耗20%的乙醇。我们发现尼古丁（0.2mg/kg和0.8mg/kg, s.c）显著增加20%乙醇的有效自我给药，而varenicline (2mg/kg, s.c) （nachr的部分激动剂）显著降低乙醇的有效自我给药和尼古丁诱导的乙醇自我给药的增加。这表明nachr在增加乙醇自我给药方面起着重要作用，并且伐尼克兰可能是酒精和尼古丁共同依赖的有效治疗方法。
Alcohol and nicotine use disorders are often treated as separate diseases, despite evidence that approximately 80–90% of alcohol dependent individuals are also heavy smokers. Both nicotine and ethanol have been shown to interact with neuronal nicotinic acetylcholine receptors (nAChRs), suggesting these receptors are a common biological target for the effects of nicotine and ethanol in the brain. There are few studies that have examined the effects of co-administered nicotine and ethanol on the activity of nAChRs in rodents. In the present study, we show that Sprague-Dawley rats, a strain often used for nicotine studies but not as often for voluntary ethanol intake studies, will consume 20% ethanol using both the intermittent-access two-bottle-choice and operant self-administration models without the need for sucrose fading. We show that nicotine (0.2mg/kg and 0.8mg/kg, s.c.) significantly increases operant 20% ethanol self-administration and varenicline (2mg/kg, s.c), a partial agonist at nAChRs, significantly decreases operant ethanol self-administration and nicotine-induced increases in ethanol self-administration. This suggests that nAChRs play an important role in increasing ethanol self-administration and that varenicline may be an efficacious treatment for alcohol and nicotine co-dependencies.
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DOI：
10.2174/187152710790966597
发表时间：
2010-03
期刊：
CNS & neurological disorders drug targets
影响因子：
--
作者：
Chatterjee S;Bartlett SE
通讯作者：
Bartlett SE
DOI：
10.1523/jneurosci.2601-10.2010
发表时间：
2010-07-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hendrickson LM;Zhao-Shea R;Pang X;Gardner PD;Tapper AR
通讯作者：
Tapper AR
DOI：
10.1007/bf00403808
发表时间：
1970-01-01
期刊：
PSYCHOPHARMACOLOGIA
影响因子：
--
作者：
AMIT, Z;STERN, MH;WISE, RA
通讯作者：
WISE, RA
影响因子：
4.2
作者：
Barrett, SP;Tichauer, M;Pihl, RO
通讯作者：
Pihl, RO
影响因子：
3.8
作者：
BLOMQVIST, O;SODERPALM, B;ENGEL, JA
通讯作者：
ENGEL, JA