Development of gut microbiota along with its metabolites of preschool children.
Development of gut microbiota along with its metabolites of preschool children.
复制标题
肠道菌群的发展以及其学龄前儿童的代谢产物。
DOI：
10.1186/s12887-021-03099-9
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发表时间：
2022-01-06
期刊：
影响因子：
2.4
通讯作者：
Huang Y
中科院分区：
文献类型：
--
作者：
Xiong J;Hu H;Xu C;Yin J;Liu M;Zhang L;Duan Y;Huang Y
目的：揭示健康学龄前儿童生长发育过程中肠道微生物丰度和组成的变化，以及胆汁酸和短链脂肪酸的微生物区系代谢水平。收集1 2 0例6 月~6 岁健康新生儿和15 0例健康儿童的粪便。用16S rRNA分析肠道菌群组成，LC-MS法检测粪便中胆汁酸含量，GS法检测粪便中短链脂肪酸含量。新生儿肠道菌群组成和功能在出生后6个月不稳定，6 时明显改善，2~3 龄后逐渐稳定并趋于成年型。短链脂肪酸和次生胆汁酸水平与肠道微生物区系的发育相一致。6个 月龄可能是儿童肠道菌群发育的关键期。网上版载有补充材料，可在10.1186/s12887-021-03099-9查阅。
To reveal the changes of intestinal microbial abundance and composition, as well as the microbiota metabolic levels of bile acids and short chain fatty acids of healthy preschool children during their growth. Feces of 120 healthy newborns and 150 healthy children aged 6 months to 6 years were collected. Then the composition of intestinal flora was analyzed by 16S rRNA, and the contents of bile acids and short chain fatty acids in feces were detected by LC-MS and GS methods, respectively. The composition and function of intestinal microflora were not stable in neonatal period but significantly improved at 6 months after birth, and gradually stabilized and tended to adult-like formation after 2–3 years old. The levels of short chain fatty acids and secondary bile acids were consistent with the development of gut microbiota. The age of 6 months may be a critical period for the development of intestinal microflora in children. The online version contains supplementary material available at 10.1186/s12887-021-03099-9.
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影响因子：
15.5
作者：
Hollister EB;Riehle K;Luna RA;Weidler EM;Rubio-Gonzales M;Mistretta TA;Raza S;Doddapaneni HV;Metcalf GA;Muzny DM;Gibbs RA;Petrosino JF;Shulman RJ;Versalovic J
通讯作者：
Versalovic J
影响因子：
5
作者：
Staley, Christopher;Weingarden, Alexa R.;Khoruts, Alexander;Sadowsky, Michael J.
通讯作者：
Sadowsky, Michael J.
胃肠道微生物组：评论。
影响因子：
2.6
作者：
Barko PC;McMichael MA;Swanson KS;Williams DA
通讯作者：
Williams DA
影响因子：
15.5
作者：
Perez-Muñoz ME;Arrieta MC;Ramer-Tait AE;Walter J
通讯作者：
Walter J
影响因子：
3.7
作者：
Ringel-Kulka T;Cheng J;Ringel Y;Salojärvi J;Carroll I;Palva A;de Vos WM;Satokari R
通讯作者：
Satokari R