Sleep as a window on the sensorimotor foundations of the developing hippocampus.
Sleep as a window on the sensorimotor foundations of the developing hippocampus.
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海马体结构在学习、记忆和相关的认知功能中起着既定的作用。最近的发现还表明，海马体整合了来自自我产生的运动的感觉反馈，以调节不断变化的环境中正在进行的运动反应。这些发现支持了海马体是感觉运动整合部位的观点。为了进一步支持这一观点，我们回顾了发育中的大鼠的神经生理学证据，即海马体功能建立在感觉运动的基础上，并且这一基础在发育早期尤为明显。此外，在海马体第一次建立与远距离感觉和运动结构的功能连接的年龄，这种连接在活跃(或快速眼动)睡眠期间优先表达。这些发现强化了这样一个概念，即睡眠作为婴儿期早期的主要状态，为感觉运动发育提供了关键的背景，包括海马体及其相关网络的发育。
The hippocampal formation plays established roles in learning, memory, and related cognitive functions. Recent findings also suggest that the hippocampus integrates sensory feedback from self-generated movements to modulate ongoing motor responses in a changing environment. Such findings support the view of that the hippocampus is a site of sensorimotor integration. In further support of this view, we review neurophysiological evidence in developing rats that hippocampal function is built on a sensorimotor foundation and that this foundation is especially evident early in development. Moreover, at those ages when the hippocampus is first establishing functional connectivity with distant sensory and motor structures, that connectivity is preferentially expressed during periods of active (or REM) sleep. These findings reinforce the notion that sleep, as the predominant state of early infancy, provides a critical context for sensorimotor development, including development of the hippocampus and its associated network.
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影响因子：
16.6
作者：
Bitzenhofer SH;Ahlbeck J;Wolff A;Wiegert JS;Gee CE;Oertner TG;Hanganu-Opatz IL
通讯作者：
Hanganu-Opatz IL
影响因子：
15.9
作者：
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3.5
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
Bender F;Gorbati M;Cadavieco MC;Denisova N;Gao X;Holman C;Korotkova T;Ponomarenko A
通讯作者：
Ponomarenko A