Acoustic droplet vaporization for enhancement of thermal ablation by high intensity focused ultrasound.
Acoustic droplet vaporization for enhancement of thermal ablation by high intensity focused ultrasound.
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DOI：
10.1016/j.acra.2011.04.012
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发表时间：
2011-09
影响因子：
4.8
通讯作者：
Fowlkes, Jeffrey Brian
中科院分区：
文献类型：
--
作者：
Zhang, Man;Fabiilli, Mario L.;Haworth, Kevin J.;Padilla, Frederic;Swanson, Scott D.;Kripfgans, Oliver D.;Carson, Paul L.;Fowlkes, Jeffrey Brian
声波液滴汽化（ADV）在空间控制和加速热损伤产生方面具有广阔的前景。我们的假设是ADV产生的微泡可以通过控制和增加局部能量吸收来增强高强度聚焦超声（HIFU）热消融。采用聚焦超声（1.44 MHz），聚焦强度为4000 W·cm-2，在37°C的脱气水中产生热损伤。通过光学不透明的可见变化和t2加权MRI测量平均病变体积。此外，在犬肝脏内静脉注射具有类似声学装置的液滴前后产生体内HIFU病变。与没有液滴的幻影相比，含有液滴的幻影（3×105液滴/mL）的热病变大7倍。在含液滴的幻影中，HIFU暴露2 s的平均病变体积与不含液滴的幻影暴露5 s的平均病变体积相当。在体内研究中，无液滴和有液滴的平均病变体积分别为0.017±0.006 cm3 （n = 4,5 s）和0.265±0.005 cm3 (n = 3,5 s)，相差15倍。b超成像的ADV气泡形状与光学和MRI测量的实际病变形状非常相似。ADV泡可以通过减少治疗时间或所需的原位总声功率来促进临床HIFU消融，并提供热疗的超声成像反馈。
Acoustic droplet vaporization (ADV) shows promise for spatial control and acceleration of thermal lesion production. Our hypothesis was that microbubbles generated by ADV could enhance high intensity focused ultrasound (HIFU) thermal ablation by controlling and increasing local energy absorption. Thermal lesions were produced in tissue-mimicking phantoms using focused ultrasound (1.44 MHz) with a focal intensity of 4000 W·cm-2 in degassed water at 37°C. The average lesion volume was measured by visible change in optical opacity and by T2-weighted MRI. In addition, in vivo HIFU lesions were generated in a canine liver before and after an intravenous injection of droplets with a similar acoustic setup. Thermal lesions were seven-fold larger in phantoms containing droplets (3×105 droplets/mL) compared to phantoms without droplets. The mean lesion volume with a 2 s HIFU exposure in droplet-containing phantoms was comparable to that made by a 5 s exposure in phantoms without droplets. In the in vivo study, the average lesion volumes without and with droplets were 0.017 ± 0.006 cm3 (n = 4, 5 s exposure) and 0.265 ± 0.005 cm3 (n = 3, 5 s exposure), respectively – a factor of 15 difference. The shape of ADV bubbles imaged with B-mode ultrasound was very similar to the actual lesion shape as measured optically and by MRI. ADV bubbles may facilitate clinical HIFU ablation by reducing treatment time or requisite in situ total acoustic power, and provide ultrasonic imaging feedback of the thermal therapy.
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DOI：
10.1016/j.jacr.2009.01.004
发表时间：
2009-07-01
期刊：
Journal of the American College of Radiology : JACR
影响因子：
--
作者：
Bradley, William G Jr
通讯作者：
Bradley, William G Jr
影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
2.9
作者：
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影响因子：
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作者：
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