The effect of Ferula elaeochytris root extract on erectile dysfunction in streptozotocin-induced diabetic rat
The effect of Ferula elaeochytris root extract on erectile dysfunction in streptozotocin-induced diabetic rat
复制标题
阿魏提取物对链脲佐菌素糖尿病大鼠勃起功能障碍的影响
DOI：
10.1038/s41443-019-0137-8
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发表时间：
2019
影响因子：
2.6
通讯作者：
Yoshiyama Mitsuharu
中科院分区：
文献类型：
--
作者：
Eser Nadire;Buyuknacar Hacer Sinem;Cimentepe Ozge Ozturk;Gocmen Cemil;Ucar Yilmaz;Erdogan Seyda;Yoshiyama Mitsuharu
勃起功能障碍（艾德）是糖尿病的重要并发症。本研究旨在探讨阿魏根提取物对链脲佐菌素（STZ）诱导的糖尿病大鼠艾德的影响。将75只成年雄性Wistar白化病大鼠等分为5组：对照组（C）、FE（40 mg/kg-d）、STZ诱导的糖尿病组（60 mg/kg）（DM）、糖尿病+F.elaeochytris（DM + FE）和乙醇（EtOH）。8周后，评估体外和体内参数（海绵体内压[ICP]）、睾丸和体重、血糖水平和组织病理学。在STZ诱导的糖尿病组，乙酰胆碱诱导的内皮依赖性舒张反应，电场刺激诱导的神经源性和氮能舒张反应显着减少，而FE给药糖尿病大鼠逆转减少的氮能和神经源性反应。糖尿病组ICP/MAP（0.1375 ± 0.02 cm/H2O），睾丸生精（53.73 ± 0.81），睾丸重量（257.8 ± 20.63）例明显减少;然而，FE给药于糖尿病大鼠恢复了降低的值（分别为0.350 ± 0.019 cm/H2O、75.07 ± 0.35和416 ± 24.11）。DM组血糖水平较C组升高（411.7 ± 18.30）。然而，与DM组相比，糖尿病大鼠的FE给药降低了葡萄糖水平（230.6 ± 25.60 mg/dL）。总之，FE恢复神经和内皮功能障碍，降低血糖水平在糖尿病大鼠。
Erectile dysfunction (ED) is an important complication of diabetes. The aim of our study was to determine whetherFerula elaeochytris(FE) root extract could affect ED in streptozotocin (STZ)-induced diabetic rats. Seventy-five adult male Wistar albino rats were equally divided into five groups; control (C), FE (40 mg/kg-d), STZ-induced diabetes (60 mg/kg) (DM), diabetes +F.elaeochytris(DM + FE), and ethanol (EtOH). After 8 weeks, in vitro and in vivo parameters (intracavernosal pressure [ICP]), testicle and body weight, serum glucose levels, and histopathology were assessed. In the STZ-induced diabetic group, acetylcholine-induced endothelium-dependent relaxation responses, and electrical field stimulation-induced neurogenic and nitrergic relaxation responses were decreased significantly, while FE administration to diabetic rats reversed the decreased nitrergic and neurogenic responses. In the diabetic group, ICP/MAP (0.1375 ± 0.02 cm/H2O), spermatogenesis in testicles (53.73 ± 0.81), and testicle weights (257.8 ± 20.63) were decreased significantly; however, FE administration to diabetic rats restored the decreased values (0.350 ± 0.019 cm/H2O, 75.07 ± 0.35, and 416 ± 24.11, respectively). In the DM group, blood glucose levels were increased (411.7 ± 18.30) compared to the C group. However, FE administration to diabetic rats reduced glucose levels (230.6 ± 25.60 mg/dL) compared to the DM group. In conclusion, FE recovered neurogenic and endothelial dysfunction and decreased glucose levels in diabetic rats.
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影响因子：
--
作者：
Raafat K;El-Lakany A
通讯作者：
El-Lakany A
DOI：
--
发表时间：
2009
期刊：
影响因子：
--
作者：
E. Kassis;S. Fulder;K. Khalil;Bahaa Hadieh;F. Nahhas;B. Saad;O. Said
通讯作者：
O. Said
DOI：
10.1007/978-94-024-1079-2_62
发表时间：
2017-01-01
期刊：
TAURINE 10
影响因子：
--
作者：
Liu, Hong;Lin, Shumei;Yang, Jiancheng
通讯作者：
Yang, Jiancheng
影响因子：
7.2
作者：
Geroushi, Afaf;Auzi, Abdurazag A.;Sarker, Satyajit D.
通讯作者：
Sarker, Satyajit D.
影响因子：
4.3
作者：
Asokkumar, Selvamani;Naveenkumar, Chandrashekar;Devaki, Thiruvengadam
通讯作者：
Devaki, Thiruvengadam