Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder.
Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder.
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DOI：
10.1002/da.20718
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发表时间：
2010-07
影响因子：
7.4
通讯作者：
Rauch, Scott L.
中科院分区：
文献类型：
--
作者：
Britton, Jennifer C.;Stewart, S. Evelyn;Killgore, William D. S.;Rosso, Isabelle M.;Price, Lauren M.;Gold, Andrea L.;Pine, Daniel S.;Wilhelm, Sabine;Jenike, Michael A.;Rauch, Scott L.
与健康对照对象相比，患有焦虑症的成年人和儿童对威胁面孔的杏仁核激活被夸大了。然而，强迫症(OCD)患者杏仁核对面部表情的激活可能是一个明显的特征；先前的一项研究发现，与健康成年人相比，强迫症患者对情绪和中性面孔的杏仁核激活较少(Cannstraro等人，2004年)。在目前的事件相关功能磁共振成像(FMRI)研究中，一名儿童强迫症样本(N=12)和一名健康对照样本(HC，N=17)在观看情绪面孔(高兴、恐惧、厌恶)和中性面孔时执行性别歧视任务。与HC组相比，强迫症组在所有情绪和中性条件下杏仁核/海马区的激活程度都低于注视。像以前关于成人强迫症的报告一样，儿童强迫症可能有不同于其他焦虑症的神经特征，就杏仁核对非疾病特异性情绪刺激的反应而言。
Exaggerated amygdala activation to threatening faces has been detected in adults and children with anxiety disorders, compared to healthy comparison subjects. However, the profile of amygdala activation in response to facial expressions in obsessive-compulsive disorder (OCD) may be a distinguishing feature; a prior study found that compared with healthy adults, adults with OCD exhibited less amygdala activation to emotional and neutral faces, relative to fixation (Cannistraro et al., 2004). In the current event-related functional magnetic resonance imaging (fMRI) study, a pediatric OCD sample (N=12) and a healthy comparison sample (HC, N=17) performed a gender discrimination task while viewing emotional faces (happy, fear, disgust) and neutral faces. Compared to the HC group, the OCD group showed less amygdala/hippocampus activation in all emotion and neutral conditions relative to fixation. Like previous reports in adult OCD, pediatric OCD may have a distinct neural profile from other anxiety disorders, with respect to amygdala activation in response to emotional stimuli that are not disorder-specific.
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