Effects of electronic cigarette heating coil resistance and liquid nicotine concentration on user nicotine delivery, heart rate, subjective effects, puff topography, and liquid consumption.
Effects of electronic cigarette heating coil resistance and liquid nicotine concentration on user nicotine delivery, heart rate, subjective effects, puff topography, and liquid consumption.
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DOI：
10.1037/pha0000337
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发表时间：
2020-10
影响因子：
2.3
通讯作者：
Eissenberg, Thomas
中科院分区：
文献类型：
--
作者：
Hiler, Marzena;Karaoghlanian, Nareg;Talih, Soha;Maloney, Sarah;Breland, Alison;Shihadeh, Alan;Eissenberg, Thomas
电子烟（ECIG）尼古丁递送和其他效果可能受到装置和/或液体特性以及用户抽吸行为的影响。一类ECIG模型包括“亚欧姆”装置，其包含电阻<1欧姆（Ω）的加热线圈，低于在常规装置中观察到的电阻（例如，≥1.5Ω）。相对于在≤ 10 W下操作的常规ECIG，低电阻线圈可用于增加装置功率（例如，40-300W）。然而，很少有人知道的ECIG功率，线圈电阻操纵，和液体尼古丁浓度对ECIG急性效应的个别和综合影响。32名经验丰富的ECIG使用者完成了4个疗程，不同的是ECIG功率/线圈电阻（40.5W; 0.5Ω或13.5W;1.5Ω）和液体尼古丁浓度（3或8 mg/ml）。在每个阶段中，参与者在10口定向（30秒IPI）和60分钟随意回合中使用4.5V“Kanger SUBOX”。测量尼古丁释放、心率、主观效应、抽吸地形和液体消耗。尼古丁递送在8 mg/ml+0.5Ω条件下最大，在3 mg/ml+1.5Ω条件下最低。在8 mg/ml+0.5 Ω条件下观察到戒断症状的最大减少，尽管在3 mg/ml+0.5Ω条件下报告了最高的愉悦度、满意度和喜爱度评分。总体而言，使用含有3 mg/ml尼古丁液体的ECIG导致更长/更大的抽吸和增加的抽吸频率，尽管高功率/低电阻ECIG导致ECIG液体的消耗更大。在做出旨在保护公众健康的监管决策时，应同时考虑ECIG电源/线圈电阻、液体尼古丁浓度和用户抽吸地形。
Electronic cigarette (ECIG) nicotine delivery and other effects can be influenced by device and/or liquid characteristics as well as user puffing behavior. One class of ECIG models includes “sub-ohm” devices that incorporate heating coils with resistance <1 ohm (Ω), lower than that observed in conventional devices (e.g., ≥1.5Ω). Relative to conventional ECIGs that operate at ≤10W, low resistance coils can be used to increase device power (e.g., 40–300W). However, little is known about the individual and combined effects of ECIG power, manipulated by coil resistance, and liquid nicotine concentration on ECIG acute effects. Thirty-two experienced ECIG users completed four sessions that differed by ECIG power/coil resistance (40.5W; 0.5Ω or 13.5W;1.5Ω), and liquid nicotine concentration (3 or 8 mg/ml). In each session, participants used a 4.5V “Kanger SUBOX” in a 10-puff directed (30 sec IPI) and 60-minute ad libitum bout. Nicotine delivery, heart rate, subjective effects, puff topography, and liquid consumption were measured. Nicotine delivery was greatest in the 8 mg/ml+0.5Ω condition and lowest in the 3 mg/ml+1.5Ω condition. The greatest reduction in abstinence symptoms were observed in the 8 mg/ml+0.5Ω condition although the highest ratings for pleasantness, satisfaction, and liking were reported in the 3 mg/ml+0.5Ω condition. Overall, use of ECIGs containing 3 mg/ml nicotine liquid resulted in longer/larger puffs and increased puff frequency though high power/low resistance ECIGs resulted in greater consumption of ECIG liquid. ECIG power/coil resistance, liquid nicotine concentration and user puff topography should be considered simultaneously when making regulatory decisions aimed at protecting public health.
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