Catecholaminergic Modulation of Conflict Control Depends on the Source of Conflicts.
Catecholaminergic Modulation of Conflict Control Depends on the Source of Conflicts.
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DOI：
10.1093/ijnp/pyy063
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发表时间：
2018-10-01
期刊：
影响因子：
--
通讯作者：
Beste C
中科院分区：
文献类型：
--
作者：
Bensmann W;Roessner V;Stock AK;Beste C
为了表现出目标导向的行为，我们必须能够解决在处理各种干扰物时产生的反应冲突。这样的冲突可以由不同种类的干扰刺激（例如，启动和侧翼刺激），但这两种冲突类型的功能和神经生物学基础是否不同仍很不清楚。因此，我们调查的功能相关的儿茶酚胺多巴胺和去甲肾上腺素，这已被证明可以增加神经元处理的信噪比，因此应调制响应冲突。在一项双盲、随机、安慰剂对照研究设计中，我们在一组n=25名健康年轻人中研究了哌甲酯（0.5 mg/kg）对侧翼诱导和引发诱导反应冲突的影响。我们使用EEG记录检查事件相关电位结合源定位分析，以确定哌甲酯调制的认知神经生理子过程和功能神经解剖结构。与安慰剂相比，哌醋甲酯减少侧翼冲突。这与额中央N2/P3事件相关电位复合体的一致性效应增加相匹配，并与右额下回的调制相关。与此相反，哌醋甲酯没有调节引发的冲突的大小。我们的研究结果表明，儿茶酚胺驱动的信噪比和神经增益控制的增加并不同样有利于不同的诱发冲突。这支持了一个假设，至少部分不同的神经生物学基础的侧翼和启动诱发的反应冲突。由于右额下回在抑制中发挥着重要作用，因此儿茶酚胺能系统可能会通过支持对分散注意力的信息的抑制来减少侧翼冲突。
To display goal-directed behavior, we must be able to resolve response conflicts that arise from processing various distractors. Such conflicts may be triggered by different kinds of distractor stimuli (e.g., priming and flanker stimuli), but it has remained largely unclear whether the functional and neurobiological underpinnings of both conflict types differ. We therefore investigated the functional relevance of the catecholamines dopamine and norepinephrine, which have been shown to increase the signal-to-noise ratio in neuronal processing and should therefore modulate response conflicts. In a double-blind, randomized, placebo-controlled study design, we examined the effect of methylphenidate (0.5 mg/kg) on both flanker-induced and priming-induced response conflicts in a group of n=25 healthy young adults. We used EEG recordings to examine event-related potentials in combination with source localization analyses to identify the cognitive-neurophysiological subprocesses and functional neuroanatomical structures modulated by methylphenidate. Compared with placebo, methylphenidate decreased flanker conflicts. This was matched by increased congruency effects in the fronto-central N2/P3 event-related potential complex and associated with modulations in the right inferior frontal gyrus. In contrast to this, methylphenidate did not modulate the size of prime-evoked conflicts. Our results suggest that catecholamine-driven increases in signal-to-noise ratio and neural gain control do not equally benefit differently evoked conflicts. This supports the hypothesis of an at least partly different neurobiological basis for flanker- and prime-evoked response conflicts. As the right inferior frontal gyrus plays an important role in inhibition, the catecholaminergic system may reduce flanker conflicts by supporting the inhibition of distracting information.
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