Organic persistent luminescence imaging for biomedical applications.

Organic persistent luminescence imaging for biomedical applications.
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DOI:
10.1016/j.mtbio.2022.100481
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发表时间:
2022-12-15
期刊:
Materials today. Bio
影响因子:
--
通讯作者:
Ding D
Ding D
中科院分区:
其他
文献类型:
--
作者:
Wu Z;Midgley AC;Kong D;Ding D

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持续发光是在激发光照射停止后或发光分子氧化后发生的独特视觉现象。储存在分子内的能量以延迟的方式释放,导致可以维持数秒、数分钟、数小时甚至数天的发光。有机持久发光材料(OPLMs)是高度稳健的,并且它们容易修饰和组装成生物相容性纳米结构使它们成为用于体内生物成像的有吸引力的工具,同时为生物医学应用提供常规荧光成像材料的替代品。在这篇综述中,我们注意到现有的限制,每一类基于OPLM的分子生物成像探针的基础上,他们的发光机制,以及如何最近的研究进展,推动努力规避他们的缺点。我们讨论了这些分子探针的多功能设计策略,以及广阔的生物应用前景。此外,我们提供的见解,下一代的OPLM正在开发的生物成像技术。
Persistent luminescence is a unique visual phenomenon that occurs after cessation of excitation light irradiation or following oxidization of luminescent molecules. The energy stored within the molecule is released in a delayed manner, resulting in luminescence that can be maintained for seconds, minutes, hours, or even days. Organic persistent luminescence materials (OPLMs) are highly robust and their facile modification and assembly into biocompatible nanostructures makes them attractive tools for in vivo bioimaging, whilst offering an alternative to conventional fluorescence imaging materials for biomedical applications. In this review, we give attention to the existing limitations of each class of OPLM-based molecular bioimaging probes based on their luminescence mechanisms, and how recent research progress has driven efforts to circumvent their shortcomings. We discuss the multifunctionality-focused design strategies, and the broad biological application prospects of these molecular probes. Furthermore, we provide insights into the next generation of OPLMs being developed for bioimaging techniques.
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