Association of maternal heavy metal exposure during pregnancy with isolated cleft lip and palate in offspring: Japan Environment and Children's Study (JECS) cohort study.
Association of maternal heavy metal exposure during pregnancy with isolated cleft lip and palate in offspring: Japan Environment and Children's Study (JECS) cohort study.
复制标题
DOI：
10.1371/journal.pone.0265648
复制
发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Japan Environment and Children’s Study Group
中科院分区：
文献类型：
--
作者：
Takeuchi M;Yoshida S;Kawakami C;Kawakami K;Ito S;Japan Environment and Children’s Study Group
唇腭裂（L/P 裂）是最常见的先天性异常之一，其病因被认为是多因素的。最近涉及少数参与者的流行病学数据表明，围产期接触重金属与受影响儿童的 L/P 裂之间存在关联。然而，这种关联需要在大量队列中进行进一步研究。这项巢式病例对照研究使用了日本环境与儿童研究的数据集，该研究是一个正在进行的研究项目，旨在调查环境因素与母婴健康之间的关联。参与者于2011年至2014年间入组。从胎儿/儿童的记录中，我们以1:10的比例提取了孤立的L/P裂病例和匹配的无裂L/P病例的数据。感兴趣的暴露是在子宫内暴露于四种金属（汞 [Hg]、铅 [Pb]、镉 [Cd] 和锰 [Mn]），这些金属是从妊娠中期/晚期的母亲身上取样的。条件逻辑回归用于评估重金属暴露与孤立裂 L/P 之间的关联。进行了三项敏感性分析来测试研究结果的稳健性，包括病例定义和统计方法的变化。在涉及活产和死产的 104,062 份胎儿记录中，我们确定了 192 名患有孤立性唇裂的儿童和 1,920 名匹配的对照儿童。总体而言，血液金属水平较低（例如，总队列、病例和对照组的中位 Pb 水平分别为 5.85、6.22 和 5.75 μg/L）。单变量和多变量分析表明，怀孕期间母亲血液中四种重金属的水平与后代 L/P 裂的风险无关。 Hg、Pb、Cd 和 Mn 的调整优势比（每增加 1 μg/L）在 95% 区间内分别为 0.96 (0.91–1.03)、1.01 (0.94–1.08)、1.00 (0.61–1.63) 和 1.00 (0.97–1.03)。所有敏感性分析的结果都是一致的。在我们的队列中，在低暴露水平下，怀孕期间接触这四种金属与孤立的 L/P 裂无关。
Cleft lip and palate (cleft L/P) is one of the most common congenital anomalies and its etiology is assumed to be multifactorial. Recent epidemiological data involving a small number of participants suggested an association between perinatal exposure to heavy metals and cleft L/P in affected children. However, this association requires further investigation in a large cohort. This nested case–control study used a dataset of The Japan Environment and Children’s Study, which is an ongoing research project to investigate the association between environmental factors and mother-child health. Participants were enrolled between 2011 and 2014. From the records of fetuses/children, we extracted data of isolated cleft L/P cases and matched children without cleft L/P at a ratio of 1:10. The exposures of interest were in utero exposure to four metals (mercury [Hg], lead [Pb], cadmium [Cd], and manganese [Mn]), which were sampled from mothers in the second/third trimester. Conditional logistic regression was used to assess the association between heavy metal exposure and isolated cleft L/P. Three sensitivity analyses were conducted to test the robustness of the findings, including the change in case definition and statistical methods. Of 104,062 fetal records involving both live-birth and stillbirth, we identified 192 children with isolated cleft L/P and 1,920 matched controls. Overall, the blood metal levels were low (for example, median Pb level was 5.85, 6.22, and 5.75 μg/L in the total cohort, cases, and controls, respectively). Univariate and multivariate analyses showed that levels of none of the four heavy metals in the mother’s blood during pregnancy were associated with the risk of cleft L/P in offspring; the adjusted odds ratios (per 1 μg/L increase) with 95% intervals were 0.96 (0.91–1.03), 1.01 (0.94–1.08), 1.00 (0.61–1.63) and 1.00 (0.97–1.03) for Hg, Pb, Cd and Mn, respectively. The results were consistent in all sensitivity analyses. Exposure to these four metals during pregnancy was not associated with isolated cleft L/P at the low exposure level in our cohort.
登录
查看更多内容
影响因子：
7.7
作者：
Liew, Zeyan;Olsen, Jorn;Arah, Onyebuchi A.
通讯作者：
Arah, Onyebuchi A.
影响因子：
3.1
作者：
Mbuyi-musanzayi, Sebastien;Kayembe, Tony J.;Reychler, Herve
通讯作者：
Reychler, Herve
影响因子：
5.8
作者：
Pan, Libo;Wang, Yue;Xiang, Bao
通讯作者：
Xiang, Bao
影响因子：
8.9
作者：
Pi, Xin;Qiao, Yiran;Ren, Aiguo
通讯作者：
Ren, Aiguo
影响因子：
6.7
作者：
Signes-Pastor AJ;Desai G;García-Villarino M;Karagas MR;Kordas K
通讯作者：
Kordas K