Exposure to a mixture of metals and growth indicators in 6-11-year-old children from the 2013-16 NHANES.
Exposure to a mixture of metals and growth indicators in 6-11-year-old children from the 2013-16 NHANES.
复制标题
2013-16年NHANES中6-11岁儿童接触金属混合物和生长指标。
DOI：
10.1007/s12403-020-00371-8
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发表时间：
2021-06
影响因子：
6.7
通讯作者：
Kordas K
中科院分区：
文献类型：
--
作者：
Signes-Pastor AJ;Desai G;García-Villarino M;Karagas MR;Kordas K
儿童期铅（Pb）、汞（Hg）和氟化物（F）的暴露因其毒性而令人担忧。此外，有证据表明，在这一脆弱时期，锰（Mn）和硒（Se）的高和低暴露水平与不良健康影响的风险增加有关。一个减少的增长与高铅和氟暴露，但是，鲜为人知的是，他们对儿童的身体大小的影响，并缺乏共识的汞，锰，硒暴露对儿童的人体测量措施的影响。在与一般人群相关的水平上，儿童期金属共暴露尤其如此。我们调查了暴露于金属混合物（血液中的铅、锰、汞和硒以及血浆中的氟）对6-11岁美国儿童（n = 1，634）人体测量的联合影响。中位F、Pb、Mn、Hg和Se浓度分别为0.3 μmol/L、0.5 μg/dL、10.2 μg/L、0.3 μg/L和178.0 μg/L。使用贝叶斯核机器和线性回归对五种金属的联合效应进行建模。铅和锰与所有测量结果呈相反方向的关联，其中铅与人体测量呈负相关。对于身体质量指数和腰围，铅和锰的影响估计出现在高浓度和低浓度的其他金属的混合物，分别较强。我们的研究结果表明，金属共暴露可能会影响儿童的体重和线性生长指标，这种关系可能会因金属混合物成分的暴露水平而异。
Lead (Pb), mercury (Hg) and fluoride (F) exposure during childhood is of concern owing to their toxicity. Also, evidence suggests that high and low exposure levels to manganese (Mn) and selenium (Se) during this vulnerable period are associated with an increased risk of adverse health effects. A reduced growth is associated with high Pb and F exposure; however, little is known about their impact on children’s body size, and there is a lack of consensus on the effects of Hg, Mn, and Se exposure on children’s anthropometric measures. This is particularly true for childhood metal co-exposures at levels relevant to the general population. We investigated the joint effects of exposure to a metal mixture (Pb, Mn, Hg, and Se in blood and F in plasma) on 6-11-year-old US children’s anthropometry (n = 1,634). Median F, Pb, Mn, Hg, and Se concentrations were 0.3 μmol/L, 0.5 μg/dL, 10.2 μg/L, 0.3 μg/L, and 178.0 μg/L, respectively. The joint effects of the five metals were modeled using Bayesian kernel machine and linear regressions. Pb and Mn showed opposite directions of associations with all outcome measured, where Pb was inversely associated with anthropometry. For body mass index and waist circumference, the effect estimates for Pb and Mn appeared stronger at high and low concentrations of the other metals of the mixture, respectively. Our findings suggest that metal co-exposures may influence children’s body mass and linear growth indicators, and that such relations may differ by the exposure levels of the components of the metal mixture.
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影响因子：
11.8
作者：
Coker E;Chevrier J;Rauch S;Bradman A;Obida M;Crause M;Bornman R;Eskenazi B
通讯作者：
Eskenazi B
影响因子：
11.8
作者：
Gao, Zhen-Yan;Li, Min-Ming;Yan, Chong-Huai
通讯作者：
Yan, Chong-Huai
影响因子：
11.8
作者：
Burns JS;Williams PL;Lee MM;Revich B;Sergeyev O;Hauser R;Korrick SA
通讯作者：
Korrick SA
影响因子：
5.1
作者：
Ballew, C;Khan, LK;Gunter, EW
通讯作者：
Gunter, EW
影响因子：
5
作者：
Gardner RM;Kippler M;Tofail F;Bottai M;Hamadani J;Grandér M;Nermell B;Palm B;Rasmussen KM;Vahter M
通讯作者：
Vahter M