Non-Alcoholic Fatty Liver Disease and Nutritional Implications: Special Focus on Copper.
Non-Alcoholic Fatty Liver Disease and Nutritional Implications: Special Focus on Copper.
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DOI：
10.3390/nu9101137
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发表时间：
2017-10-18
期刊：
影响因子：
5.9
通讯作者：
Barbaro B
中科院分区：
文献类型：
--
作者：
Antonucci L;Porcu C;Iannucci G;Balsano C;Barbaro B
非酒精性脂肪性肝病（NAFLD）的特征是肝细胞中脂质过多，这是由于脂肪组织中脂肪酸过量流入、肝脏脂肪从头生成以及膳食脂肪和碳水化合物摄入过多所致。慢性肝脂质超负荷会诱导线粒体氧化应激和细胞损伤，导致 NAFLD 发展为更严重的肝病，即非酒精性脂肪性肝炎 (NASH)。反过来，这可能发展为肝硬化和肝细胞癌（HCC）。其中，铜是参与生理氧化还原反应的大部分酶所需的主要生物金属之一，该反应主要发生在线粒体呼吸过程中。因此，铜稳态可以被认为是对抗 NAFLD 进展的目标点。因此，许多疾病与铜水平不平衡有关，实际上，一些临床试验正在检查铜螯合剂的使用。目前，尚未批准针对 NAFLD 的药物干预措施，但始终建议调整营养和生活方式。文献中已经描述了被认为可以改善 NAFLD 及其并发症的抗氧化食品制剂可以与铜结合。因此，本综述描述了营养在 NAFLD 发生和进展中的作用，特别关注铜和铜结合抗氧化剂化合物对抗 NAFLD。
Non-alcoholic fatty liver disease (NAFLD) is characterized by excess lipids in hepatocytes, due to excessive fatty acid influx from adipose tissue, de novo hepatic lipogenesis, in addition to excessive dietary fat and carbohydrate intake. Chronic hepatic lipid overload induces mitochondrial oxidative stress and cellular damage leading the development of NAFLD into a more severe liver disease condition, non-alcoholic steato-hepatitis (NASH). In turn, this can progress to cirrhosis and hepatocellular carcinoma (HCC). Among others, copper is one of the main bio-metals required for the preponderance of the enzymes involved in physiological redox reactions, which primarily occurs during mitochondrial respiration. Thus, copper homeostasis could be considered a target point for counteracting the progression of NAFLD. Accordingly, many diseases are correlated to unbalanced copper levels and, actually, some clinical trials are examining the use of copper chelating agents. Currently, no pharmacological interventions are approved for NAFLD, but nutritional and lifestyle modifications are always recommended. Fittingly, antioxidant food agents recognized to improve NAFLD and its complications have been described in the literature to bind copper. Therefore, this review describes the role of nutrition in the development and progression of NAFLD with a particular focus on copper and copper-binding antioxidant compounds against NAFLD.
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影响因子：
3.5
作者：
Bissig, KD;Honer, M;Solioz, M
通讯作者：
Solioz, M
影响因子：
3
作者：
Hung, Vinci Wing Sze;Bressan, Lucas Paines;Kerman, Kagan
通讯作者：
Kerman, Kagan
影响因子：
4.6
作者：
Dorts J;Falisse E;Schoofs E;Flamion E;Kestemont P;Silvestre F
通讯作者：
Silvestre F
影响因子：
5.6
作者：
Gambino R;Bugianesi E;Rosso C;Mezzabotta L;Pinach S;Alemanno N;Saba F;Cassader M
通讯作者：
Cassader M
影响因子：
29
作者：
Farese RV Jr;Zechner R;Newgard CB;Walther TC
通讯作者：
Walther TC