Effects of monoaminergic drugs on training-induced motor cortex plasticity in older adults.
Effects of monoaminergic drugs on training-induced motor cortex plasticity in older adults.
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单胺能药物对老年人训练诱导的运动皮层可塑性的影响。
DOI：
10.1016/j.brainres.2017.06.015
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发表时间：
2017-09-01
期刊：
影响因子：
2.9
通讯作者：
Buetefisch CM
中科院分区：
文献类型：
--
作者：
Kesar TM;Belagaje SR;Pergami P;Haut MW;Hobbs G;Buetefisch CM
初级运动皮层（M1）的可塑性参与运动学习和中风运动恢复，并通过增加单胺能传递而增强。年龄影响这些过程，但缺乏系统的研究单胺能药物在老年人的影响。在这里，在10个老年人（年龄61 + 4岁，4名男性），我们确定了一个单一的口服剂量的卡比多巴/左旋多巴（多巴），D-苯丙胺（AMPH），哌甲酯（MEPH）和安慰剂（PLAC）对M1兴奋性和运动训练诱导的M1可塑性的影响。M1可塑性被定义为与训练相关的M1兴奋性和训练运动学的长期持续变化。在峰值血浆水平的药物，受试者训练的手腕伸展运动30分钟。结果的措施是运动诱发电位（MEP）引起的经颅磁刺激强度增加（刺激反应曲线，SRC）和峰值加速度的训练手腕伸展运动。在培训完成之前和之后采取措施。从SRC中提取曲线参数平台（MEPmax）、拐点和斜率。在基线药物对曲线参数有不同的影响，而运动学保持不变。单独训练（PLAC）增加了MEPmax，但没有改善运动学。药物影响训练相关的变化的曲线参数不同，但没有提高他们或运动学相比，PLAC。结果表明，在老年人中，MEPH，DOPA或AMPH对基线M1兴奋性和训练相关的M1可塑性有不同的影响，但未能将它们提高到幼稚水平以上。
Primary motor cortex (M1) plasticity is involved in motor learning and stroke motor recovery, and enhanced by increasing monoaminergic transmission. Age impacts these processes but there is a paucity of systematic studies on the effects of monoaminergic drugs in older adults. Here, in ten older adults (age 61 + 4 years, 4 males), we determine the effects of a single oral dose of carbidopa/levodopa (DOPA), D-amphetamine (AMPH), methylphenidate (MEPH) and placebo (PLAC) on M1 excitability and motor training-induced M1 plasticity. M1 plasticity is defined as training related long lasting changes in M1 excitability and kinematics of the trained movement. At peak plasma level of the drugs, subjects trained wrist extension movements for 30 min. Outcome measures were motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation at increasing intensity (stimulus response curve, SRC) and peak acceleration of the trained wrist extension movements. Measures were obtained before and after completion of training. The curve parameters plateau (MEPmax), inflection point, and slope were extracted from SRC. At baseline drugs had a differential effect on curve parameters, while kinematics remained unchanged. Training alone (PLAC) increased MEPmax but did not improve kinematics. Drugs affected training-related changes of the curve parameters differently, but did not enhance them or kinematics when compared to PLAC. The results demonstrate that in the older adults, MEPH, DOPA, or AMPH have differential effects on baseline M1 excitability and training-related M1 plasticity but fail to enhance them above the naïve level.
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2
作者：
Cirillo, John;Rogasch, Nigel C.;Semmler, John G.
通讯作者：
Semmler, John G.
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