Shared Functions of Perirhinal and Parahippocampal Cortices: Implications for Cognitive Aging.

Shared Functions of Perirhinal and Parahippocampal Cortices: Implications for Cognitive Aging.
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DOI:
10.1016/j.tins.2018.03.001
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发表时间:
2018-06
影响因子:
15.9
通讯作者:
Ryan L
Ryan L
中科院分区:
医学1区
文献类型:
--
作者:
Burke SN;Gaynor LS;Barnes CA;Bauer RM;Bizon JL;Roberson ED;Ryan L

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关于嗅周皮质(PRC)和嗅后/海马旁皮质(POR/PHC)功能的主要观点认为,这些结构分别用于表示物体和空间信息。然而,已知的解剖学连接,沿着最近的电生理学、神经成像和病变数据,表明两个脑区都参与空间和非空间处理。而不是基于内容的组织,PRC和PHC/POR可能参与两个计算上不同的皮质-海马网络:一个网络调整到快速处理粗糙的信息,形成gist-like表示的场景/环境;其他网络调整到处理信息的具体感官细节需要跨感官模态的歧视。现有数据表明,后一种网络在老年人中可能更脆弱。
A predominant view of perirhinal cortex (PRC) and postrhinal/parahippocampal cortex (POR/PHC) function contends that these structures are tuned to represent objects and spatial information, respectively. Known anatomical connectivity, along with recent electrophysiological, neuroimaging, and lesion data, however, indicate that both brain areas participate in spatial and nonspatial processing. Rather than content-based organization, the PRC and PHC/POR may participate in two computationally distinct cortical-hippocampal networks: one network tuned to process coarse information quickly, forming gist-like representations of scenes/environments; the other network tuned to process information about specific sensory details necessary for discrimination across sensory modalities. Available data suggest that the latter network may be more vulnerable in advanced age.
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