Non-dioxin-like polychlorinated biphenyls and risk of endometriosis.
Non-dioxin-like polychlorinated biphenyls and risk of endometriosis.
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DOI：
10.1289/ehp.0901444
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发表时间：
2010-09
影响因子：
10.4
通讯作者：
Holt VL
中科院分区：
文献类型：
--
作者：
Trabert B;De Roos AJ;Schwartz SM;Peters U;Scholes D;Barr DB;Holt VL
子宫内膜异位症是一种影响美国8-10%育龄妇女的妇科疾病，定义为子宫外存在子宫内膜组织，与盆腔疼痛和不孕有关。环境污染物，包括多氯联苯（PCBs），被认为是通过影响类固醇激素而导致子宫内膜异位症的风险。我们评估了血清中某些非共面多氯联苯的浓度，这些多氯联苯没有或只有微弱的二恶英样性质，作为子宫内膜异位症的危险因素。在华盛顿州西部的一项病例对照研究中，对1996年至2001年新诊断的手术证实的子宫内膜异位症病例（n = 251）和年龄和参考年匹配的女性对照（n = 538）血清中的20种PCB同系物进行了测定。总PCB浓度和雌激素PCB浓度与子宫内膜异位症风险无关[总：比值比（OR）= 1.3; 95%置信区间（CI），0.8-2.2;雌激素：OR = 1.1; 95% CI，0.8-1.4]。尽管几种同源物特异性OR在统计学上高于或低于零值，（PCB 170：第三四分位数与最低：OR = 0.5; 95% CI，0.3-0.9; PCB 196：第三四分位数与最低：OR = 0.4; 95% CI，0.2-0.7; PCB 201：第二与最低：OR = 0.5; 95% CI，0.3-0.8;第三四分位数与最低：OR = 0.4; 95%CI，0.2-0.7），没有子宫内膜异位症风险的总体一致模式。与其他北美研究的背景下，我们的研究结果表明，非共面PCB浓度范围内的暴露一致，目前在西部华盛顿州没有有意义的子宫内膜异位症的风险。
Endometriosis, a gynecologic disorder affecting 8–10% of reproductive-age women in the United States, is defined as the presence of endometrial tissue outside the uterus and is linked to pelvic pain and infertility. Environmental contaminants, including polychlorinated biphenyls (PCBs), are hypothesized to contribute to endometriosis risk through effects on steroid hormones. We evaluated serum concentrations of certain noncoplanar PCBs, which have no or only weak dioxin-like properties, as risk factors for endometriosis. In a case–control study of Group Health enrollees in western Washington State, 20 PCB congeners were measured in serum from surgically confirmed endometriosis cases that were newly diagnosed between 1996 and 2001 (n = 251) and from female controls matched for age and reference year (n = 538). Summed and estrogenic PCB concentrations were not associated with endometriosis risk [summed: odds ratio (OR) = 1.3; 95% confidence interval (CI), 0.8–2.2; estrogenic: OR = 1.1; 95% CI, 0.8–1.4]. Although several congener-specific ORs were statistically above or below the null (PCB 170: third quartile vs. lowest: OR = 0.5; 95% CI, 0.3–0.9; PCB 196: third quartile vs. lowest: OR = 0.4; 95% CI, 0.2–0.7; PCB 201: second vs. lowest: OR = 0.5; 95% CI, 0.3–0.8; third quartile vs. lowest: OR = 0.4; 95% CI, 0.2–0.7), there were no overall consistent patterns of endometriosis risk. Taken in context with other North American studies, our findings suggest that noncoplanar PCB concentrations consistent within the range of exposure currently observed in western Washington State do not contribute meaningfully to endometriosis risk.
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影响因子：
4
作者：
PHILLIPS, DL;PIRKLE, JL;NEEDHAM, LL
通讯作者：
NEEDHAM, LL
影响因子：
11.4
作者：
Decastro, BR;Korrick, SA;Soto, AM
通讯作者：
Soto, AM
影响因子：
2.6
作者：
Fierens, S;Mairesse, H;Bernard, A
通讯作者：
Bernard, A
影响因子：
6.1
作者：
Louis, GMB;Weiner, JM;Kostyniak, PJ
通讯作者：
Kostyniak, PJ
DOI：
10.1016/s0889-8545(05)70302-8
发表时间：
1997-06-01
影响因子：
3.2
作者：
Eskenazi, B;Warner, ML
通讯作者：
Warner, ML