Olfactory Measures as Predictors of Conversion to Mild Cognitive Impairment and Alzheimer's Disease.
Olfactory Measures as Predictors of Conversion to Mild Cognitive Impairment and Alzheimer's Disease.
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DOI：
10.3390/brainsci11111391
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发表时间：
2021-10-23
期刊：
影响因子：
3.3
通讯作者：
Murphy C
中科院分区：
文献类型：
--
作者：
Wheeler PL;Murphy C
背景：前驱阿尔茨海默病（AD）的早期生物标志物对于启动干预措施和选择临床试验参与者至关重要。AD患者的气味阈值、气味识别和气味熟悉度受损。方法：我们研究了标准筛查（MMSE）和嗅觉测量预测从认知正常（CN）到轻度认知障碍（MCI）、从CN到AD、从MCI到AD转变的相对能力。来自UCSD ADRC的497份档案样本，包括CN、MCI、AD和MCI或AD的转换者。Apoe ε4遗传风险因子256例，其中ε4携带者132例。接受者工作特征曲线（ROC）曲线描绘了敏感性和特异性之间的权衡关系。ROC曲线下面积（AUC）用于判断诊断的准确性。结果：不同的测量方法能更好地预测特定阶段的疾病风险；例如，气味熟悉度、气味识别和气味组合对ε4携带者从MCI转化为AD的预测价值高于MMSE。结合气味熟悉度和气味识别得到ε4携带者的AUC为1.0，单独的MMSE为0.58。结论：嗅觉生物标志物作为阿尔茨海默病前驱期的非侵入性指标具有真正的前景。这些结果支持了结合嗅觉测量在评估MCI和AD转换风险中的价值。
Background: Early biomarkers of prodromal Alzheimer’s disease (AD) are critical both to initiate interventions and to choose participants for clinical trials. Odor threshold, odor identification and odor familiarity are impaired in AD. Methods: We investigated the relative abilities of standard screening (MMSE) and olfactory measures to predict transitions from cognitively normal (CN) to mild cognitive impairment (MCI), from CN to AD, and MCI to AD. The archival sample of 497, from the UCSD ADRC, included participants who were CN, MCI, AD and converters to MCI or AD. Apoe ε4 status, a genetic risk factor, was available for 256 participants, 132 were ε4 carriers. A receiver operating characteristic curve (ROC) curve plots the trade-off between sensitivity and specificity. Area under the ROC curve (AUC) was used to determine diagnostic accuracy. Results: Different measures were better predictors at specific stages of disease risk; e.g., odor familiarity, odor identification and the combination showed higher predictive value for converting from MCI to AD in ε4 carriers than the MMSE. Combining odor familiarity and odor identification produced an AUC of 1.0 in ε4 carriers, MMSE alone was 0.58. Conclusions: Olfactory biomarkers show real promise as non-invasive indicators of prodromal AD. The results support the value of combining olfactory measures in assessment of risk for conversion to MCI and to AD.
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影响因子：
4.2
作者：
Djordjevic, Jelena;Jones-Gotman, Marilyn;Chertkow, Howard
通讯作者：
Chertkow, Howard
DOI：
10.1111/j.1749-6632.1998.tb10651.x
发表时间：
1998-01-01
期刊：
OLFACTION AND TASTE XII
影响因子：
--
作者：
Bacon, AW;Bondi, MW;Murphy, C
通讯作者：
Murphy, C
影响因子：
11.2
作者：
Arnold, Steven E.;Lee, Edward B.;Moberg, Paul J.;Stutzbach, Lauren;Kazi, Hala;HanMs, Li-Ying;Lee, Virginia M. Y.;Trojanowski, John Q.
通讯作者：
Trojanowski, John Q.
影响因子：
4.6
作者：
Josefsson M;Larsson M;Nordin S;Adolfsson R;Olofsson J
通讯作者：
Olofsson J
DOI：
10.1017/s1355617714000010
发表时间：
2014-02
影响因子：
2.6
作者：
Bondi, Mark W.;Smith, Glenn E.
通讯作者：
Smith, Glenn E.