Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China.
Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China.
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我国茯苓多糖作为抗肿瘤药物的分子基础
DOI：
10.1111/jcmm.13564
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发表时间：
2019-01
影响因子：
5.3
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Li X;He Y;Zeng P;Liu Y;Zhang M;Hao C;Wang H;Lv Z;Zhang L
茯苓是一种食用药用真菌，中文称为“茯苓”，作为中药已有两千多年的历史。药理研究表明，多糖是茯苓中含量最丰富的物质，具有广泛的生物活性，包括抗肿瘤、免疫调节、抗炎、抗氧化、抗衰老、抗肝炎、抗糖尿病、抗出血热等作用。于是，自20世纪70年代以来，“茯苓多糖口服液”被开发并作为非处方保健品销售。 2015年，“茯苓多糖口服液”被国家食品药品监督管理局批准为用于单独治疗多种癌症、肝炎等疾病或在癌症患者化疗、放射治疗过程中治疗多种疾病的药品。本文总结了过去 46 年（1970-2016 年）基于 PubMed、VIP（重庆维普中文科学期刊数据库）、CNKI（中国知网）和万方数据库检索的 72 项独立研究中茯苓多糖的生化、临床前和临床研究。对茯苓多糖的结构、药理作用、临床疗效、免疫平衡分子机制和毒性进行了探讨，以期为茯苓多糖作为临床抗肿瘤药物的应用提供概况。
Poria cocos is an edible medicinal fungus known as “Fuling” in Chinese and has been used as a Chinese traditional medicine for more than two thousand years. Pharmacological studies reveal that polysaccharide is the most abundant substance in Poria cocos and has a wide range of biological activities including antitumour, immunomodulation, anti‐inflammation, antioxidation, anti‐ageing, antihepatitis, antidiabetics and anti‐haemorrhagic fever effects. As a result, “Poria cocos polysaccharide oral solution” was developed and sold as an over‐the‐counter health supplement since 1970s. In 2015, “Polysaccharidum of Poria cocos oral solution” was approved as a drug by Chinese Food and Drug Administration for treating multiple types of cancers, hepatitis and other diseases alone or during chemo‐ or radiation therapy for patients with cancer. In this article, biochemical, preclinical and clinical studies of Poria cocos polysaccharide from 72 independent studies during the past 46 years (1970‐2016) based on PubMed, VIP (Chongqing VIP Chinese Scientific Journals Database), CNKI (China National Knowledge Infrastructure) and Wanfang database searches are summarized. The structure, pharmacological effects, clinical efficacy, immunobalancing molecular mechanism and toxicity of Poria cocos polysaccharide are deliberated to provide a general picture of Poria cocos polysaccharide as a clinically used antitumour drug.
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影响因子：
5.6
作者：
Chen, Xiaoyu;Zhang, Lina;Cheung, Peter Chi Keung
通讯作者：
Cheung, Peter Chi Keung
影响因子：
3.1
作者：
Jin, Y;Zhang, L;Chen, LG
通讯作者：
Chen, LG
DOI：
10.1254/jjp.59.89
发表时间：
1992-05-01
期刊：
JAPANESE JOURNAL OF PHARMACOLOGY
影响因子：
--
作者：
HATTORI, T;HAYASHI, K;SUZUKI, Y
通讯作者：
SUZUKI, Y
影响因子：
64.8
作者：
CHIHARA, G;HAMURO, J;FUKUOKA, F
通讯作者：
FUKUOKA, F
影响因子：
2.9
作者：
Huang, QL;Zhang, L
通讯作者：
Zhang, L