Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions.
Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions.
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DOI：
10.3390/nu8110706
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发表时间：
2016-11-05
期刊：
影响因子：
5.9
通讯作者：
Dos Santos RV
中科院分区：
文献类型：
--
作者：
Caris AV;Da Silva ET;Dos Santos SA;Lira FS;Oyama LM;Tufik S;Dos Santos RV
简介：在相当于海拔 4200 米的缺氧环境下进行运动与炎症介质升高和 Th1/Th2 反应变化相关。相比之下，当在含氧量正常的条件下进行运动时，补充碳水化合物具有抗炎作用。本研究的目的是评估在模拟海拔 4200 m 的缺氧条件下运动后补充碳水化合物对细胞因子和细胞损伤标志物的影响。方法：七名成年男性志愿者在三种不同的条件下随机评估，他们以 50% VO2Peak 的强度锻炼 60 分钟；常氧、缺氧和缺氧+碳水化合物补充。在休息时、运动结束时和恢复 60 分钟后采集血样。为了评估缺氧+碳水化合物补充，志愿者在运动和恢复期间每 20 分钟接受 6% 碳水化合物溶液（麦芽糖糊精）或安慰剂（草莓味 Crystal Light®；卡夫食品，诺斯菲尔德，伊利诺伊州，美国）。统计分析包括方差分析、单向方差分析以及显着性水平为 p < 0.05 的 Tukey 事后检验。结果：常氧和低氧条件下，运动后和恢复后IL-6浓度较静息时显着升高（p < 0.05），而低氧+碳水化合物组运动后IL-6和TNF-α浓度较静息时显着升高（p < 0.05）。此外，在此条件下，与休息时相比，恢复后TNF-α、IL-2和IL-2/IL-4平衡增加（p < 0.05）。结论：我们得出结论，补充碳水化合物可以改变 IL-6 和 TNF-α 血清浓度，并将 IL-2/IL-4 平衡转向 Th1，从而做出反应，而没有血糖、谷氨酰胺血症和细胞损伤的影响。
Introduction: Exercise performed at the hypoxia equivalent of an altitude of 4200 m is associated with elevated inflammatory mediators and changes in the Th1/Th2 response. By contrast, supplementation with carbohydrates has an anti-inflammatory effect when exercise is performed under normoxic conditions. The objective of this study was to evaluate the effect of carbohydrate supplementation on cytokines and cellular damage markers after exercise under hypoxic conditions at a simulated altitude of 4200 m. Methods: Seven adult male volunteers who exercised for 60 min at an intensity of 50% VO2Peak were randomly evaluated under three distinct conditions; normoxia, hypoxia and hypoxia + carbohydrate supplementation. Blood samples were collected at rest, at the end of exercise and after 60 min of recovery. To evaluate hypoxia + carbohydrate supplementation, volunteers received a solution of 6% carbohydrate (maltodextrin) or a placebo (strawberry-flavored Crystal Light®; Kraft Foods, Northfield, IL, USA) every 20 min during exercise and recovery. Statistical analyses comprised analysis of variance, with a one-way ANOVA followed by the Tukey post hoc test with a significance level of p < 0.05. Results: Under normoxic and hypoxic conditions, there was a significant increase in the concentration of IL-6 after exercise and after recovery compared to at rest (p < 0.05), while in the hypoxia + carbohydrate group, there was a significant increase in the concentration of IL-6 and TNF-α after exercise compared to at rest (p < 0.05). Furthermore, under this condition, TNF-α, IL-2 and the balance of IL-2/IL-4 were increased after recovery compared to at rest (p < 0.05). Conclusion: We conclude that carbohydrate supplementation modified the IL-6 and TNF-α serum concentrations and shifted the IL-2/IL-4 balance towards Th1 in response without glycemic, glutaminemia and cell damage effects.
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影响因子：
9.8
作者：
Mazzeo, Robert S.
通讯作者：
Mazzeo, Robert S.
DOI：
10.1519/jsc.0000000000000470
发表时间：
2014-10-01
影响因子：
3.2
作者：
Ihalainen, Johanna K.;Vuorimaa, Timo;Mero, Antti A.
通讯作者：
Mero, Antti A.
影响因子：
3.8
作者：
Hartmann, G;Tschöp, M;Toepfer, M
通讯作者：
Toepfer, M
DOI：
10.1097/aco.0b013e32834873fd
发表时间：
2011-08
期刊：
Current opinion in anaesthesiology
影响因子：
--
作者：
Koeppen M;Eckle T;Eltzschig HK
通讯作者：
Eltzschig HK
影响因子：
4.4
作者：
Caris, Aline V.;Lira, Fabio S.;dos Santos, Ronaldo V. T.
通讯作者：
dos Santos, Ronaldo V. T.