A Review of the Role of Oral Microbiome in the Development, Detection, and Management of Head and Neck Squamous Cell Cancers.
A Review of the Role of Oral Microbiome in the Development, Detection, and Management of Head and Neck Squamous Cell Cancers.
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DOI：
10.3390/cancers14174116
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发表时间：
2022-08-25
期刊：
影响因子：
5.2
通讯作者：
Porosnicu, Mercedes
中科院分区：
文献类型：
--
作者：
Burcher, Kimberly M.;Burcher, Jack T.;Inscore, Logan;Bloomer, Chance H.;Furdui, Cristina M.;Porosnicu, Mercedes
关键词：
头颈部鳞状细胞癌(HNSCC)是美国第七种最常见的癌症。虽然微生物群在其他呼吸道疾病的发展中的作用已经明确，但微生物群在HNSCC中的作用仍是一个发展中的课题。利用微生物群来预防、检测和治疗HNSCC的概念在肿瘤学中是一个令人兴奋的新前景。这篇手稿讨论了健康的口腔微生物组，头颈部癌前病变特有的微生物组，HNSCC的微生物组，以及作为免疫和恶性肿瘤调节器的微生物组。该手稿还讨论了微生物组的临床应用，因为它们与HNSCC有关，包括微生物组与结果数据之间的关系，以及治疗毒性。本综述的目的是指导未来关于微生物群的研究和临床试验，希望改善筛查技术，减少治疗毒性，提高HNSCC患者的生存率。微生物组在头颈部鳞状细胞癌(HNSCC)的发展和传播中的作用在很大程度上是未知的，周围的知识落后于已发现的与微生物组和其他恶性肿瘤相关的知识。在这篇综述中，作者对几个数据库中的可用文献进行了结构化分析。作者讨论了几项研究的利弊，讨论了HNSCC发展过程中空气消化系统结构的微生物组，微生物组在恶性肿瘤(一般和HNSCC)发展中的作用，以及微生物组在HNSCC中的临床应用。需要进一步的研究来充分描述HNSCC和微生物组之间的关系，并将这种关系推向研究环境之外具有临床相关性的空间。
Head and neck squamous cell cancers (HNSCC) are the seventh most common form of cancer in the United States. Though the role of the microbiome in the development of other diseases of the aerodigestive tract is well defined, the role of the microbiome in HNSCC is a developing subject. The notion of harnessing the microbiome for the prevention, detection, and treatment of HNSCC is an exciting new prospect in oncology. This manuscript discusses what is known about the healthy oral microbiome, the microbiome unique to premalignant lesions of the head and neck, the microbiome of HNSCC, and the microbiome as a modulator of immunity and malignancy. The manuscript also discusses clinical applications of the microbiome as they relate to HNSCC, including relationships between the microbiome and outcome data, and treatment toxicities. The aim of this review is to guide future research and clinical trials on the microbiome with the hopes of improving screening techniques, decreasing treatment toxicities, and improving survival for patients with HNSCC. The role of the microbiome in the development and propagation of head and neck squamous cell cancer (HNSCC) is largely unknown and the surrounding knowledge lags behind what has been discovered related to the microbiome and other malignancies. In this review, the authors performed a structured analysis of the available literature from several databases. The authors discuss the merits and detriments of several studies discussing the microbiome of the structures of the aerodigestive system throughout the development of HNSCC, the role of the microbiome in the development of malignancies (generally and in HNSCC) and clinical applications of the microbiome in HNSCC. Further studies will be needed to adequately describe the relationship between HNSCC and the microbiome, and to push this relationship into a space where it is clinically relevant outside of a research environment.
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DOI：
10.3322/caac.21398
发表时间：
2017-07-08
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Bhatt AP;Redinbo MR;Bultman SJ
通讯作者：
Bultman SJ
影响因子：
30.3
作者：
Backhed, Fredrik;Roswall, Josefine;Jun, Wang
通讯作者：
Jun, Wang
影响因子：
4.6
作者：
Banerjee S;Tian T;Wei Z;Peck KN;Shih N;Chalian AA;O'Malley BW;Weinstein GS;Feldman MD;Alwine J;Robertson ES
通讯作者：
Robertson ES
影响因子：
3.8
作者：
Almstahl, A.;Wikstrom, M.;Fagerberg-Mohlin, B.
通讯作者：
Fagerberg-Mohlin, B.
影响因子：
16.6
作者：
Dubin K;Callahan MK;Ren B;Khanin R;Viale A;Ling L;No D;Gobourne A;Littmann E;Huttenhower C;Pamer EG;Wolchok JD
通讯作者：
Wolchok JD