The optimum zinc content in set calcium phosphate cement for promoting bone formation in vivo.
The optimum zinc content in set calcium phosphate cement for promoting bone formation in vivo.
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DOI：
10.1016/j.msec.2008.08.021
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发表时间：
2009-04-30
影响因子：
7.9
通讯作者：
LeGeros, Racquel Z.
中科院分区：
文献类型：
--
作者：
Li, Xia;Sogo, Yu;Ito, Atsuo;Mutsuzaki, Hirotaka;Ochiai, Naoyuki;Kobayashi, Takayuki;Nakamura, Satoshi;Yamashita, Kimihiro;LeGeros, Racquel Z.
关键词：
本研究的最终目的是研制一种新型的基于含锌α-磷酸三钙(α)的磷酸钙骨水泥，并在体内评价其作为骨移植材料的潜力。本研究探讨了锌在α锌钛合金硬化体中的体内效应。将纯α或α锌粉分别与12%(质量分数)琥珀酸钠溶液以2.0%的固液比混合，制得锌含量分别为0.0 0、0.0 4、0.0 8、0.11和0.19wt%的α锌粉硬化体。由于在养护过程中锌离子释放到生理盐溶液中，计算出硬化体中的锌含量分别为0.00、0.03、0.06、0.10和0.18wt%。将硬化体植入大白兔股骨和胫骨内4周。组织学和组织形态计量学评价表明，含0.03wt%锌的硬化体与不含锌的硬化体相比，显著促进了新骨的形成，而没有引起不良组织反应。含锌0.06wt%和0.10wt%的硬化体也导致新骨周围活跃的成骨细胞数量增加，但在种植部位引起炎症。本研究结果表明，α锌钙钛矿粉制备的硬化体由于锌离子的释放，在促进新骨形成方面优于α锌钙钛矿粉。本研究还表明，为了避免炎症反应，硬化体中锌的最佳加入量为0.03wt%左右。
The final aim of our study is to develop a novel calcium phosphate cement based on zinc-containing α-tricalcium phosphate (αZnTCP) and evaluate its potential as bonegraft material in vivo. In the present study, in vivo efficacy of zinc in hardened bodies of αZnTCP was explored. The hardened bodies prepared from αZnTCP with zinc content of 0.00, 0.04, 0.08, 0.11 and 0.19 wt % were prepared by mixing pure αTCP or αZnTCP powder with 12 wt% sodium succinate solution at a solid-to-liquid ratio of 2.0. Due to the release of zinc ions into the physiological salt solution during curing, the zinc content in the hardened bodies was calculated to be 0.00, 0.03, 0.06, 0.10 and 0.18 wt%, respectively. The hardened bodies were implanted in the femora and tibia of white rabbits for 4 weeks. Histological and histomorphometric evaluation showed that the hardened body containing 0.03 wt% zinc, significantly promoted more new bone formation without evoking adverse tissue reactions than that without zinc. The hardened bodies containing 0.06 and 0.10 wt% zinc also resulted in the increase in numbers of active osteoblasts surrounding the new bone but caused inflammation at the implant sites. Results of this study indicate that the hardened body prepared with αZnTCP is superior to that prepared with αTCP in promoting new bone formation due to the release of zinc ions. This study also indicates that the optimum amount of zinc in the hardened body is about 0.03 wt % to avoid inflammatory reaction.
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影响因子：
3.9
作者：
Cerovic, Aleksandra;Miletic, Ivanka;El-Sohemy, Ahmed
通讯作者：
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影响因子：
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作者：
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通讯作者：
Brown, PW
DOI：
10.1023/a:1014336517741
发表时间：
2002-04-01
影响因子：
3.7
作者：
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通讯作者：
Brook, IM
影响因子：
4.1
作者：
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通讯作者：
Mosekilde, L