Control group design, contamination and drop-out in exercise oncology trials: a systematic review.
Control group design, contamination and drop-out in exercise oncology trials: a systematic review.
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DOI：
10.1371/journal.pone.0120996
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
May AM
中科院分区：
文献类型：
--
作者：
Steins Bisschop CN;Courneya KS;Velthuis MJ;Monninkhof EM;Jones LW;Friedenreich C;van der Wall E;Peeters PH;May AM
在癌症患者中进行运动试验的重要考虑因素是对照组成员中的污染和差异脱落，这可能会危及内部效度。这篇系统性综述概述了运动-肿瘤学试验的不同对照组设计特征，并探讨了与污染和脱落率的相关性。纳入了两篇科克伦综述中的随机对照运动肿瘤学试验。此外，在科克伦综述完成后，使用Medline（Pubmed）、Embase和CINAHL进行了计算机辅助检索。符合条件的研究根据三个对照组设计特征进行分类：在研究开始前给予对照组的运动指导（允许或不允许运动）;以及在研究期间给予对照组的干预（任何（例如，教育会话或电话联系）或无）或之后（任何（例如，交叉或练习指导）或无）干预期。污染（是或否）和过度辍学率（即，对照组的脱落率减去运动组的脱落率），根据对照组的三个设计特征以及根据这三个特征的组合进行描述;因此，我们还根据接受指导的类型和时间的组合进行了亚组。根据预先规定的合格性标准，纳入了40项运动-肿瘤学试验。在干预期后提供干预的对照组中，发现污染最低（研究的7.1%）和辍学率最低（超额辍学率-4.7至9.2）。当对照组在干预期间和之后接受干预时，污染率（0%）和超额辍学率（-10.0 ~12.8%）甚至更低。在研究干预期间和之后接受干预的对照组的污染率和辍学率较低。目前的研究结果可以考虑在设计未来的运动肿瘤学试验。
Important considerations for exercise trials in cancer patients are contamination and differential drop-out among the control group members that might jeopardize the internal validity. This systematic review provides an overview of different control groups design characteristics of exercise-oncology trials and explores the association with contamination and drop-out rates. Randomized controlled exercise-oncology trials from two Cochrane reviews were included. Additionally, a computer-aided search using Medline (Pubmed), Embase and CINAHL was conducted after completion date of the Cochrane reviews. Eligible studies were classified according to three control group design characteristics: the exercise instruction given to controls before start of the study (exercise allowed or not); and the intervention the control group was offered during (any (e.g., education sessions or telephone contacts) or none) or after (any (e.g., cross-over or exercise instruction) or none) the intervention period. Contamination (yes or no) and excess drop-out rates (i.e., drop-out rate of the control group minus the drop-out rate exercise group) were described according to the three design characteristics of the control group and according to the combinations of these three characteristics; so we additionally made subgroups based on combinations of type and timing of instructions received. 40 exercise-oncology trials were included based on pre-specified eligibility criteria. The lowest contamination (7.1% of studies) and low drop-out rates (excess drop-out rate -4.7±9.2) were found in control groups offered an intervention after the intervention period. When control groups were offered an intervention both during and after the intervention period, contamination (0%) and excess drop-out rates (-10.0±12.8%) were even lower. Control groups receiving an intervention during and after the study intervention period have lower contamination and drop-out rates. The present findings can be considered when designing future exercise-oncology trials.
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影响因子：
5.3
作者：
Arbane, Gill;Tropman, David;Garrod, Rachel
通讯作者：
Garrod, Rachel
影响因子：
2.6
作者：
Dodd MJ;Cho MH;Miaskowski C;Painter PL;Paul SM;Cooper BA;Duda J;Krasnoff J;Bank KA
通讯作者：
Bank KA
DOI：
10.1136/bmj.e70
发表时间：
2012-01-30
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Fong DY;Ho JW;Hui BP;Lee AM;Macfarlane DJ;Leung SS;Cerin E;Chan WY;Leung IP;Lam SH;Taylor AJ;Cheng KK
通讯作者：
Cheng KK
影响因子：
2.3
作者：
Dunn, G;Maracy, M;Tomenson, B
通讯作者：
Tomenson, B
影响因子：
23.4
作者：
Galvao, Daniel A.;Spry, Nigel;Newton, Robert U.
通讯作者：
Newton, Robert U.