Emotional arousal and multiple memory systems in the mammalian brain.
Emotional arousal and multiple memory systems in the mammalian brain.
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DOI：
10.3389/fnbeh.2012.00014
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发表时间：
2012
影响因子：
3
通讯作者：
Goodman J
中科院分区：
文献类型：
--
作者：
Packard MG;Goodman J
由压力和/或焦虑引起的情绪唤醒可以对哺乳动物的学习和记忆过程产生复杂的影响。最近的研究已经开始将情绪唤醒对记忆影响的研究与早期的研究联系起来，这些研究表明，记忆是在大脑的多个系统中组织起来的，这些系统根据它们所调解的记忆的“类型”而有所不同。具体来说，这些研究考察了情绪唤醒是否会对海马和背纹状体分别负责的“认知”和刺激反应“习惯”记忆过程产生不同的影响。有证据表明，应激或周围注射促焦虑药物可使动物和人类在双重解决任务中倾向于使用纹状体依赖的习惯记忆，在这种任务中，基于海马和纹状体的策略都可以提供适当的解决方案。在基底外侧杏仁核内（BLA）使用促焦虑药物也会产生习惯记忆的倾向，这与该脑区在调节情绪唤醒对记忆的调节作用中所起的传入投射的良好记录相一致。在一些学习情境中，倾向于使用由情绪唤醒产生的习惯记忆似乎是由于对海马体依赖的认知记忆的损害作用。鉴于适应不良习惯行为在各种人类精神病理中的潜在作用，进一步研究将情感和多种记忆系统的相对使用联系起来的神经机制应该是有用的。
Emotional arousal induced by stress and/or anxiety can exert complex effects on learning and memory processes in mammals. Recent studies have begun to link study of the influence of emotional arousal on memory with earlier research indicating that memory is organized in multiple systems in the brain that differ in terms of the “type” of memory they mediate. Specifically, these studies have examined whether emotional arousal may have a differential effect on the “cognitive” and stimulus-response “habit” memory processes sub-served by the hippocampus and dorsal striatum, respectively. Evidence indicates that stress or the peripheral injection of anxiogenic drugs can bias animals and humans toward the use of striatal-dependent habit memory in dual-solution tasks in which both hippocampal and striatal-based strategies can provide an adequate solution. A bias toward the use of habit memory can also be produced by intra-basolateral amygdala (BLA) administration of anxiogenic drugs, consistent with the well documented role of efferent projections of this brain region in mediating the modulatory influence of emotional arousal on memory. In some learning situations, the bias toward the use of habit memory produced by emotional arousal appears to result from an impairing effect on hippocampus-dependent cognitive memory. Further research examining the neural mechanisms linking emotion and the relative use of multiple memory systems should prove useful in view of the potential role for maladaptive habitual behaviors in various human psychopathologies.
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影响因子：
3.5
作者：
Bremner, JD
通讯作者：
Bremner, JD
DOI：
10.1016/s0091-6773(74)92231-7
发表时间：
1974-01-01
期刊：
BEHAVIORAL BIOLOGY
影响因子：
--
作者：
HIRSH, R
通讯作者：
HIRSH, R
影响因子：
2.7
作者：
Hawley, Wayne R.;Grissom, Elin M.;Dohanich, Gary P.
通讯作者：
Dohanich, Gary P.
影响因子：
3.2
作者：
GUY, AP;GARDNER, CR
通讯作者：
GARDNER, CR
影响因子：
3.6
作者：
HANDLEY, SL;MITHANI, S
通讯作者：
MITHANI, S