Dorsolateral and dorsomedial prefrontal gray matter density changes associated with bipolar depression.
Dorsolateral and dorsomedial prefrontal gray matter density changes associated with bipolar depression.
复制标题
背外侧和背侧前额叶灰质密度与躁郁症抑郁有关。
DOI：
10.1016/j.pscychresns.2008.06.007
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发表时间：
2009-06-30
影响因子：
2.3
通讯作者：
Ketter, Terence A.
中科院分区：
文献类型：
--
作者：
Brooks, John O., III;Bonner, Julie C.;Rosen, Allyson C.;Wang, Po W.;Hoblyn, Jennifer C.;Hill, Shelley J.;Ketter, Terence A.
情绪状态与脑血流和代谢的改变有关，但大脑结构的变化通常被视为持久的特征，遗传倾向或慢性精神疾病的结果。磁共振成像（MRI）扫描获得了两组患者的双相情感障碍。在一组中，患者符合当前重度抑郁发作的标准，而在另一组中没有患者符合。两组中均无患者符合当前躁狂、轻躁狂或混合发作的标准。各组在年龄和疾病严重程度方面相匹配。用统计参数图软件（SPM 5）进行灰质密度分析。与非抑郁的双相情感障碍者相比，抑郁的双相情感障碍者在右背外侧和双侧背内侧前额叶皮质和左顶叶部分区域表现出较低的灰质密度。此外，抑郁症患者左侧颞叶和右侧后扣带回/海马旁回的灰质密度高于非抑郁症患者。我们的发现强调了情绪状态在大脑结构研究中的重要性，而这个问题迄今为止还没有得到足够的关注。此外，我们观察到的灰质密度的差异重叠的代谢领域的变化，从而对情感障碍的概念化和治疗的影响。
Mood states are associated with alterations in cerebral blood flow and metabolism, yet changes in cerebral structure are typically viewed in the context of enduring traits, genetic predispositions, or the outcome of chronic psychiatric illness. Magnetic resonance imaging (MRI) scans were obtained from two groups of patients with bipolar disorder. In one group, patients met criteria for a current major depressive episode whereas in the other no patient did. No patient in either group met criteria for a current manic, hypomanic, or mixed episode. Groups were matched with respect to age and illness severity. Analyses of gray matter density were performed with Statistical Parametric Mapping software (SPM5). Compared with non-depressed bipolar subjects, depressed bipolar subjects exhibited lower gray matter density in the right dorsolateral and bilateral dorsomedial prefrontal cortices and portions of the left parietal lobe. In addition, gray matter density was greater in the left temporal lobe and right posterior cingulate cortex/parahippocampal gyrus in depressed than in non-depressed subjects. Our findings highlight the importance of mood state in structural studies of the brain—an issue that has received insufficient attention to date. Moreover, our observed differences in gray matter density overlap metabolic areas of change and thus have implications for the conceptualization and treatment of affective disorders.
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影响因子：
5.7
作者：
Nugent, AC;Milham, MP;Drevets, WC
通讯作者：
Drevets, WC
影响因子：
16.2
作者：
Mayberg, HS;Lozano, AM;Kennedy, SH
通讯作者：
Kennedy, SH
影响因子：
168.9
作者：
Moore, GJ;Bebchuk, JM;Menji, HK
通讯作者：
Menji, HK
DOI：
10.1076/jcen.23.1.121.1223
发表时间：
2001-02-01
影响因子：
2.2
作者：
Liotti, M;Mayberg, HS
通讯作者：
Mayberg, HS
影响因子：
10.6
作者：
Bearden, Carrie E.;Thompson, Paul M.;Soares, Jair C.
通讯作者：
Soares, Jair C.