Increasing resistance to multiple anthelmintic classes in gastrointestinal nematodes on sheep farms in southwest England.
Increasing resistance to multiple anthelmintic classes in gastrointestinal nematodes on sheep farms in southwest England.
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DOI：
10.1002/vetr.1531
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发表时间：
2022-06
影响因子：
2.2
通讯作者：
Morgan, Eric R.
中科院分区：
文献类型：
--
作者：
Bull, Katie;Glover, Mike J.;Vineer, Hannah Rose;Morgan, Eric R.
全球范围内，胃肠道线虫对驱虫剂的抗药性(AR)正在增加，并鼓励农民采取可持续的控制措施。缠绕血圆线虫在英国的报告越来越多，可能会使有效的杜松子酒控制变得复杂。2016年，英国德文郡北部的13个农场进行了粪蛋计数减少测试(FECRT)。用花生凝集素染色定量螺旋杆菌的相对丰度，并使用eggCounts R包估计粪卵计数减少百分比(FeCr%)。平均而言，农场对三种驱虫剂有杜松子酒抗性。没有一个农场对所有测试的驱虫剂都有敏感性。2016年的AR比2013年的相同农场更普遍。在接受测试的农场中，有85%的农场存在螺旋体，在治疗前平均占杜松子酒鸡蛋的6%(0%-52%)。在不同的农场观察到对所有测试的驱虫剂的抗药性或疑似抗药性。结果表明，在农场的AR曲线的多样性，AR在3年内的明显进展，以及在混合物种感染中检测AR的挑战。在可能的情况下，对混合物种FECRT的解释应考虑到治疗前后物种的相对丰富程度，以确定针对个别属的实用治疗选择。
Anthelmintic resistance (AR) in gastrointestinal nematodes (GIN) is increasing globally, and farmers are encouraged to adopt sustainable control measures. Haemonchus contortus is increasingly reported in the UK, potentially complicating effective GIN control. Faecal egg count reduction tests (FECRT) were conducted on 13 farms in north Devon, England, UK in 2016. Relative abundance of H. contortus was quantified using peanut agglutinin staining and used to estimate faecal egg count reduction percentages (FECR%) using the eggCounts R package. On average, farms had GIN resistance to three anthelmintic classes. No farms had susceptibility to all anthelmintics tested. AR was more prevalent in 2016 than on the same farms in 2013. H. contortus was present on 85% of the farms tested and comprised on average 6% (0%–52%) of GIN eggs before treatment. Resistance or suspected resistance to all anthelmintics tested was observed in this species on different farms. The results demonstrate diversity of AR profiles on farms, apparent progression of AR within a 3‐year period, and challenges detecting AR in mixed‐species infections. Where possible, interpretation of mixed‐species FECRT should take into account the relative abundance of species pre‐ and post‐treatment to identify pragmatic treatment options targeting individual genera.
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影响因子：
2.6
作者：
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通讯作者：
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影响因子：
1.9
作者：
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通讯作者：
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