A spontaneous depressive pattern in adult female rhesus macaques.
A spontaneous depressive pattern in adult female rhesus macaques.
复制标题
成年雌性恒河猴的自发抑郁模式
DOI：
10.1038/srep11267
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发表时间：
2015-06-10
影响因子：
4.6
通讯作者：
Hu X
中科院分区：
文献类型：
--
作者：
Qin D;Rizak J;Chu X;Li Z;Yang S;Lü L;Yang L;Yang Q;Yang B;Pan L;Yin Y;Chen L;Feng X;Hu X
非人类灵长类动物提供了独特的机会来研究根源于行为和生理异常的抑郁症的发展。本研究观察了成年雌性恒河猴的社会等级，旨在描述伴随抑郁样行为的生理和大脑异常。对来自14个不同繁殖群体的31只雌性恒河猴的行为进行了录像，并采用焦点动物技术对录像进行了分析。有13只猴子从未表现出蜷缩行为（非蜷缩者）。其余18只猴子根据在蜷缩姿势中花费的平均时间分为两组。4只猴子被指定为高蜷缩者，而其他14只猴子则是低蜷缩者。社会地位和抑郁症之间存在反比关系。高蜷缩者花更多的时间进行身体接触，并在接近其他猴子，以及更少的时间自发和反应性的迁移，比低蜷缩者和/或非蜷缩者。从头发中测得的皮质醇水平显着升高，在高蜷缩者与低蜷缩者和非蜷缩者相比，测得的皮质醇水平特别是高蜷缩者比下属或占主导地位的控制猴子。局部脑血流量数据显示，与非蜷缩者相比，高蜷缩者的脑血流量显著且广泛减少。
Non-human primates offer unique opportunities to study the development of depression rooted in behavioral and physiological abnormalities. This study observed adult female rhesus macaques within social hierarchies and aimed to characterize the physiological and brain abnormalities accompanying depressive-like behavior. The behaviors of 31 female rhesus macaques from 14 different breeding groups were video recorded, and the footage was analyzed using the focal animal technique. There were 13 monkeys who never displayed huddling behavior (non-huddlers). The remaining 18 monkeys were divided into two groups according the mean time spent in the huddle posture. Four monkeys were designated as high huddlers, whereas the other 14 monkeys were low huddlers. An inverse relationship was discovered between social rank and depression. High huddlers spent more time engaging in physical contact and in close proximity to other monkeys, as well as less time spontaneously and reactively locomoting, than low huddlers and/or non-huddlers. Cortisol levels measured from the hair were elevated significantly in high huddlers compared with low huddlers and non-huddlers, and the measured cortisol levels were specifically higher in high huddlers than subordinate or dominant control monkeys. Regional cerebral blood flow data revealed significant and widespread decreases in high huddlers compared with non-huddlers.
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影响因子：
10.6
作者：
Drevets, WC
通讯作者：
Drevets, WC
影响因子：
6.7
作者：
Holthoff, VA;Beuthien-Baumann, B;Herholz, K
通讯作者：
Herholz, K
影响因子：
0.3
作者：
Jeon, Hong Jin
通讯作者：
Jeon, Hong Jin
影响因子：
3.3
作者：
Gillespie, CF;Nemeroff, CB
通讯作者：
Nemeroff, CB
影响因子：
2.7
作者：
Paul, IA;English, JA;Halaris, A
通讯作者：
Halaris, A