Platelet proteins, including platelet-derived growth factor, specifically depress a subset of the multiple components of the response elicited by glutathione in Hydra.
Platelet proteins, including platelet-derived growth factor, specifically depress a subset of the multiple components of the response elicited by glutathione in Hydra.
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血小板蛋白，包括血小板衍生的生长因子，特异性抑制水螅中谷胱甘肽引起的反应的多种成分的一部分。
DOI：
10.1083/jcb.104.6.1675
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发表时间：
1987-06
期刊：
影响因子：
--
通讯作者：
Ross R
中科院分区：
文献类型：
--
作者：
Hanai K;Kato H;Matsuhashi S;Morita H;Raines EW;Ross R
人血清更强烈地抑制了由S-甲基谷胱甘肽引起的水螅（球形成）的摄食反应比血浆。根据血小板释放的几种蛋白质的作用，提出了至少五种明显的反应组分（R1-R5）。每一种血小板蛋白质都能特异性地抑制这些成分的一个子集。在检测的血小板蛋白中，血小板衍生生长因子（PDGF）特异性地抑制R2反应（抑制效果为最大值的50%时的浓度[ED 50]为0.17 pM），碱性成纤维细胞生长因子抑制R3和R5反应（ED 50 0.50 aM）和R2反应（ED 50 0.55 pM）。对于PDGF对R2反应的抑制，加入抗PDGF IgG或化学还原PDGF，这两者都阻止PDGF与反应细胞上的细胞表面受体结合，消除了PDGF对水螅反应的抑制作用。这些意见的影响进行了讨论。
Human serum more strongly depressed the feeding response of Hydra (ball formation) elicited by S-methylglutathione than plasma. On the basis of the effect of several proteins released by platelets, at least five apparent components of the response (R1-R5) were suggested. Each of the platelet proteins examined specifically depressed a subset of these components. Among the platelet proteins examined, platelet-derived growth factor (PDGF) specifically depressed the R2 response (the concentration at which the depressing effect was 50% of the maximum [ED50] was 0.17 pM), and basic fibroblast growth factor depressed the R3 and R5 responses (ED50 0.50 aM) and the R2 response (ED50 0.55 pM). With respect to the depression of the R2 response by PDGF, addition of an anti-PDGF IgG or chemical reduction of PDGF, both of which prevent PDGF from binding to its cell surface receptor on responsive cells, eliminated the depressing effect of PDGF on the hydra response. The implications of these observations are discussed.
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DOI：
10.1073/pnas.68.2.271
发表时间：
1971-01-01
影响因子：
11.1
作者：
BALK, SD
通讯作者：
BALK, SD
DOI：
10.1085/jgp.45.2.331
发表时间：
1961-11
期刊：
The Journal of general physiology
影响因子：
--
作者：
LENHOFF HM
通讯作者：
LENHOFF HM
DOI：
10.1073/pnas.82.19.6507
发表时间：
1985-01-01
影响因子：
11.1
作者：
ESCH, F;BAIRD, A;GUILLEMIN, R
通讯作者：
GUILLEMIN, R
DOI：
10.1073/pnas.76.4.1809
发表时间：
1979-01-01
影响因子：
11.1
作者：
ANTONIADES, HN;SCHER, CD;STILES, CD
通讯作者：
STILES, CD
DOI：
10.1073/pnas.78.6.3669
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
GROTENDORST, GR;SEPPA, HEJ;MARTIN, GR
通讯作者：
MARTIN, GR