Impact of malnutrition on systemic immune and metabolic profiles in type 2 diabetes.
Impact of malnutrition on systemic immune and metabolic profiles in type 2 diabetes.
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DOI：
10.1186/s12902-020-00649-7
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发表时间：
2020-11-12
影响因子：
2.7
通讯作者：
Babu S
中科院分区：
文献类型：
--
作者：
Rajamanickam A;Munisankar S;Dolla CK;Thiruvengadam K;Babu S
虽然肥胖和超重状况是 2 型糖尿病 (T2DM) 的明确危险因素，但相当大比例的糖尿病患者，尤其是在非洲和亚洲，往往体重不足或正常体重。然而，人们对这些个体的免疫学和代谢特征知之甚少。本研究旨在评估营养不良与 2 型糖尿病 (T2DM) 之间的关系。我们检查了与体重指数 (BMI) 低 (<18.5kg/m2) 或正常 (18.5-24.9kg/m2) 的 T2DM 个体的免疫和代谢特征相关的多种分析物。为此，我们测量了低BMI（LBMI）或正常BMI（NBMI）T2DM个体的HbA1c、葡萄糖、胰岛素、胰高血糖素、脂肪细胞因子以及1型、2型、17型、促炎和调节细胞因子的血浆水平，每组样本量n = 44。与 NBMI 个体相比，LBMI 个体的 HbA1c、随机血糖、胰岛素和胰高血糖素水平显着更高。同样，与 NBMI 个体相比，LBMI 个体表现出显着较高的脂联素和脂肪素水平，以及显着较低的瘦素水平。与 NBMI 个体相比，LBMI 个体还表现出 1 型、2 型、17 型、促炎性和调节性细胞因子水平显着较低。最后，代谢参数与BMI呈显着负相关，而免疫学参数与BMI呈显着正相关。营养不良与 T2DM 中血糖、激素和细胞因子参数的显着调节有关。因此，T2DM 的生化和免疫学特征显着受 BMI 影响。在线版本包含可在 10.1186/s12902-020-00649-7 获取的补充材料。
While obesity and overweight status are firmly established risk factors for Type 2 diabetes mellitus (T2DM), a substantial proportion of diabetic individuals, especially in Africa and Asia, are often underweight or normal weight. However, very little is known about the immunological and metabolic profiles of these individuals. This study aimed to assess the relationship between malnutrition and Type 2 diabetes mellitus (T2DM). We examined a variety of analytes associated with the immunological and metabolic profiles of T2DM individuals with low (< 18.5 kg/m2) or normal (18.5–24.9 kg/m2) body mass index (BMI). To this end, we measured plasma levels of HbA1c, glucose, insulin, glucagon, adipocytokines and Type 1, Type 2, Type 17, pro-inflammatory and regulatory cytokines in T2DM individuals with low BMI (LBMI) or normal BMI (NBMI) with small sample size n = 44 in each group. LBMI individuals exhibited significantly higher levels of HbA1c, random blood glucose, insulin and glucagon compared to NBMI individuals. Similarly, LBMI individuals exhibited significantly higher levels of adiponectin and adipsin and significantly lower levels of leptin in comparison to NBMI individuals. LBMI individuals also exhibited significantly lower levels of the Type 1, Type 2, Type 17, pro-inflammatory and regulatory cytokines in comparison to NBMI individuals. Finally, while the metabolic parameters exhibited a significant negative correlation with BMI, the immunological parameters exhibited a significant positive correlation with BMI. Malnutrition is associated with a significant modulation of glycemic, hormonal and cytokine parameters in T2DM. Hence, the biochemical and immunological profiles of T2DM is significantly influenced by BMI. The online version contains supplementary material available at 10.1186/s12902-020-00649-7.
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炎症和代谢疾病中的脂肪因子。
DOI：
10.1038/nri2921
发表时间：
2011-02
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
168.9
作者：
Black, Robert E.;Victora, Cesar G.;Uauy, Ricardo
通讯作者：
Uauy, Ricardo
影响因子：
4.8
作者：
Little, Matthew;Humphries, Sally;Dewey, Cate
通讯作者：
Dewey, Cate
影响因子：
7.3
作者：
Rajamanickam A;Munisankar S;Thiruvengadam K;Menon PA;Dolla C;Nutman TB;Babu S
通讯作者：
Babu S
影响因子：
3.7
作者：
Rahman SA;Adjeroh D
通讯作者：
Adjeroh D