Different types of recombination events are controlled by the RAD1 and RAD52 genes of Saccharomyces cerevisiae.
Different types of recombination events are controlled by the RAD1 and RAD52 genes of Saccharomyces cerevisiae.
复制标题
不同类型的重组事件由酿酒酵母的 RAD1 和 RAD52 基因控制。
DOI:
10.1093/genetics/120.2.367
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发表时间:
1988
期刊:
影响因子:
3.3
通讯作者:
Klein,HL
中科院分区:
文献类型:
--
作者:
Klein,HL
Intrachromosomal recombination within heteroallelic duplications located on chromosomes III and XV of Saccharomyces cerevisiae has been examined. Both possible orientations of alleles have been used in each duplication. Three recombinant classes, gene conversions, pop-outs and triplications, were recovered. Some of the recombinant classes were not anticipated from the particular allele orientation of the duplication. Recovery of these unexpected recombinants requires the RAD1 gene. These studies show that RAD1 has a role in recombination between repeated sequences, and that the recombination event is a gene conversion associated with a crossover. These events appear to involve very localized conversion of a heteroduplex region and are distinct from RAD52 mediated gene conversion events. Evidence is also presented to suggest that most recombination events between direct repeats are intrachromatid, not between sister chromatids.
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