Sex-Related Differences in White Matter Asymmetry and Its Implications for Verbal Working Memory in Psychosis High-Risk State.
Sex-Related Differences in White Matter Asymmetry and Its Implications for Verbal Working Memory in Psychosis High-Risk State.
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白质不对称性的性别相关差异及其对精神病高风险状态的言语工作记忆的影响。
DOI：
10.3389/fpsyt.2021.686967
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发表时间：
2021
影响因子：
4.7
通讯作者：
Mulert C
中科院分区：
文献类型：
--
作者：
Steinmann S;Lyall AE;Langhein M;Nägele FL;Rauh J;Cetin-Karayumak S;Zhang F;Mussmann M;Billah T;Makris N;Pasternak O;O'Donnell LJ;Rathi Y;Kubicki M;Leicht G;Shenton ME;Mulert C
目的：精神分裂症的性二型性已被研究，尽管临床高危人群中的性别差异尚无定论。本研究旨在通过研究慢性阻塞性肺疾病患者与健康对照组之间与言语工作记忆相关的四条白质束的不对称性，来表征大脑中语言区域的性别二型性。HC典型地表现为这些束的向左不对称。此外，不对称的结构异常和言语工作记忆功能障碍与神经发育异常有关，被认为是精神分裂症的核心特征。方法：29例慢性精神分裂症患者(女性17例，男性12例)和21例(女性11例，男性10例)年龄、性别、文化程度相匹配的精神分裂症患者作为研究对象。采用双张量无味卡尔曼滤波束成像技术，结合自动、图谱引导的纤维丛聚类方法，识别与言语工作记忆相关的四条纤维束：上纵束(SLF)I、II、III和枕额上束(SOIF)。以组织的分数各向异性(FA)为主要衡量指标，计算出每一束的偏侧指数。结果：CHR女性SLF-III的左、右不对称性显著大于HC女性，但CHR与HC男性之间的半球差异无统计学意义。此外，CHR女性SLF-III的偏侧性指数与后向数字广度表现呈负相关，表明向右不对称性越大，工作记忆功能越差。结论：本研究提示CHR女性SLF-III向右不对称性增加。在慢性阻塞性肺疾病患者大脑中与语言相关的区域中，白质不对称的性别二型性的发现突显了需要更深入地理解性别在高危状态中的作用。未来研究早期性别特异性病理生理机制的工作，可能会导致开发新的个性化治疗策略，旨在防止过渡到更慢性和更难治疗的疾病。
Objective: Sexual dimorphism has been investigated in schizophrenia, although sex-specific differences among individuals who are at clinical high-risk (CHR) for developing psychosis have been inconclusive. This study aims to characterize sexual dimorphism of language areas in the brain by investigating the asymmetry of four white matter tracts relevant to verbal working memory in CHR patients compared to healthy controls (HC). HC typically show a leftward asymmetry of these tracts. Moreover, structural abnormalities in asymmetry and verbal working memory dysfunctions have been associated with neurodevelopmental abnormalities and are considered core features of schizophrenia. Methods: Twenty-nine subjects with CHR (17 female/12 male) for developing psychosis and twenty-one HC (11 female/10 male) matched for age, sex, and education were included in the study. Two-tensor unscented Kalman filter tractography, followed by an automated, atlas-guided fiber clustering approach, were used to identify four fiber tracts related to verbal working memory: the superior longitudinal fasciculi (SLF) I, II and III, and the superior occipitofrontal fasciculus (SOFF). Using fractional anisotropy (FA) of tissue as the primary measure, we calculated the laterality index for each tract. Results: There was a significantly greater right>left asymmetry of the SLF-III in CHR females compared to HC females, but no hemispheric difference between CHR vs. HC males. Moreover, the laterality index of SLF-III for CHR females correlated negatively with Backward Digit Span performance, suggesting a greater rightward asymmetry was associated with poorer working memory functioning. Conclusion: This study suggests increased rightward asymmetry of the SLF-III in CHR females. This finding of sexual dimorphism in white matter asymmetry in a language-related area of the brain in CHR highlights the need for a deeper understanding of the role of sex in the high-risk state. Future work investigating early sex-specific pathophysiological mechanisms, may lead to the development of novel personalized treatment strategies aimed at preventing transition to a more chronic and difficult-to-treat disorder.
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影响因子：
17.7
作者：
Conklin, HM;Curtis, CE;Iacono, WG
通讯作者：
Iacono, WG
影响因子：
5.7
作者：
Beaulieu, C;Plewes, C;Phillips, L
通讯作者：
Phillips, L
影响因子：
4.2
作者：
Gomez-Gastiasoro, Ainara;Zubiaurre-Elorza, Leire;Ojeda, Natalia
通讯作者：
Ojeda, Natalia
DOI：
10.1111/j.1469-7610.2010.02235.x
发表时间：
2010-04
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Correll CU;Hauser M;Auther AM;Cornblatt BA
通讯作者：
Cornblatt BA
影响因子：
2.3
作者：
Falkenberg, Liv E.;Westerhausen, Rene;Hugdahl, Kenneth
通讯作者：
Hugdahl, Kenneth