Altered connectivity pattern of hubs in default-mode network with Alzheimer's disease: an Granger causality modeling approach.
Altered connectivity pattern of hubs in default-mode network with Alzheimer's disease: an Granger causality modeling approach.
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DOI：
10.1371/journal.pone.0025546
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Yao L
中科院分区：
文献类型：
--
作者：
Miao X;Wu X;Li R;Chen K;Yao L
来自正常受试者的证据表明，默认模式网络（DMN）以后扣带皮层（PCC）、内侧前额叶皮层（MPFC）和下顶叶皮层（IPC）为枢纽；同时，这些DMN节点经常被发现在阿尔茨海默病（AD）患者中异常募集。关于这些集线器如何与 DMN 的其余节点相互作用以及集线器相对于 AD 的改变模式的问题仍在讨论中，以最终得到澄清。为了解决这些问题，我们分别使用 Granger 因果分析和图论方法对 12 名年轻受试者、16 名老年正常对照和 15 名 AD 患者的静息态 fMRI 数据研究了 DMN 内任意一对节点之间的因果影响。我们发现：（1）PCC/MPFC/IPC，尤其是PCC，对年轻群体的DMN动态表现出最广泛和独特的因果效应； (2)与老对照相比，AD患者的DMN中枢模式异常：MPFC和IPC与其他节点存在明显的因果相互作用中断； PCC表现出色，因为它是唯一与所有其他节点具有显着因果关系的区域； (3) 中枢和其他 DMN 节点之间关系的改变具有作为 AD 非侵入性生物标志物的潜力。据我们所知，我们的研究首次从因果关系的角度支持了DMN的中枢配置，并揭示了AD中DMN中枢的异常模式。年轻受试者的研究结果为 PCC/MPFC/IPC 作为 DMN 中枢的作用提供了额外的证据。与旧控制相比，MPFC 和 IPC 由于明显的因果相互作用中断而失去了枢纽的作用，而 PCC 被保留为唯一与所有其他节点显示出显着因果关系的枢纽。
Evidences from normal subjects suggest that the default-mode network (DMN) has posterior cingulate cortex (PCC), medial prefrontal cortex (MPFC) and inferior parietal cortex (IPC) as its hubs; meanwhile, these DMN nodes are often found to be abnormally recruited in Alzheimer's disease (AD) patients. The issues on how these hubs interact to each other, with the rest nodes of the DMN and the altered pattern of hubs with respect to AD, are still on going discussion for eventual final clarification. To address these issues, we investigated the causal influences between any pair of nodes within the DMN using Granger causality analysis and graph-theoretic methods on resting-state fMRI data of 12 young subjects, 16 old normal controls and 15 AD patients respectively. We found that: (1) PCC/MPFC/IPC, especially the PCC, showed the widest and distinctive causal effects on the DMN dynamics in young group; (2) the pattern of DMN hubs was abnormal in AD patients compared to old control: MPFC and IPC had obvious causal interaction disruption with other nodes; the PCC showed outstanding performance for it was the only region having causal relation with all other nodes significantly; (3) the altered relation between hubs and other DMN nodes held potential as a noninvasive biomarker of AD. Our study, to the best of our knowledge, is the first to support the hub configuration of the DMN from the perspective of causal relationship, and reveal abnormal pattern of the DMN hubs in AD. Findings from young subjects provide additional evidence for the role of PCC/MPFC/IPC acting as hubs in the DMN. Compared to old control, MPFC and IPC lost their roles as hubs owing to the obvious causal interaction disruption, and PCC was preserved as the only hub showing significant causal relations with all other nodes.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1073/pnas.0308538101
发表时间：
2004-06-29
影响因子：
11.1
作者：
Brovelli, A;Ding, MZ;Bressler, SL
通讯作者：
Bressler, SL
影响因子：
17.7
作者：
Alexander, GE;Chen, K;Reiman, EM
通讯作者：
Reiman, EM
影响因子：
16.2
作者：
Gold, BT;Buckner, RL
通讯作者：
Buckner, RL
影响因子：
5.7
作者：
Calhoun, VD;Adali, T;Pearlson, GD
通讯作者：
Pearlson, GD