Iron sparing and recycling in a compartmentalized cell.

Iron sparing and recycling in a compartmentalized cell.
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DOI:
10.1016/j.mib.2013.07.019
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发表时间:
2013-12
影响因子:
5.4
通讯作者:
Merchant SS
Merchant SS
中科院分区:
生物学2区
文献类型:
--
作者:
Blaby-Haas CE;Merchant SS

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This review focuses on economizing, prioritizing and recycling iron in Chlamydomonas, a reference organism for discovering mechanisms of acclimation to poor iron nutrition in the plant lineage. The metabolic flexibility of Chlamydomonas offers a unique opportunity to distinguish the impact of iron nutrition on photosynthetic vs. respiratory metabolism, and the contribution of sub-cellular compartments to iron storage and mobilization. Mechanisms of iron sparing include down regulation of protein abundance by transcript reduction or protein degradation. Two well studied examples of hierarchical iron allocation are the maintenance of FeSOD in the plastid and heterotrophic metabolism in acetate-grown cells at the expense of photosynthetic metabolism. The latter implicates the existence of a pathway for inter-compartment iron recycling when access to iron becomes limiting.
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