The origin and evolution of cell-intrinsic antibacterial defenses in eukaryotes.

The origin and evolution of cell-intrinsic antibacterial defenses in eukaryotes.
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DOI:
10.1016/j.gde.2019.09.002
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发表时间:
2019-10
影响因子:
4
通讯作者:
Levin, Tera C.
Levin, Tera C.
中科院分区:
生物学2区
文献类型:
--
作者:
Richter, Daniel J.;Levin, Tera C.

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为了在一个由细菌主导的世界中生存,真核生物进化出了许多自卫策略。虽然一些防御措施是最近的进化创新,但其他防御措施则是古老的,早在真核生物历史中就有根源。在抗菌免疫方面,我们强调了检测细菌的模式识别受体的进化,其中多种功能类别已经从一小部分蛋白质结构域的重复使用和再利用中形成。接下来,我们将讨论真核生物共享的核心杀微生物策略,以及这些系统如何从古老的细胞机制中被吸收。我们提出,研究不同真核生物的抗菌反应可以揭示新的防御模式,同时强调在我们自身免疫系统进化早期发生的关键创新。
To survive in a world dominated by bacteria, eukaryotes have evolved numerous self-defense strategies. While some defenses are recent evolutionary innovations, others are ancient, with roots early in eukaryotic history. With a focus on antibacterial immunity, we highlight the evolution of pattern recognition receptors that detect bacteria, where diverse functional classes have been formed from the repeated use and reuse of a small set of protein domains. Next, we discuss core microbicidal strategies shared across eukaryotes, and how these systems may have been co-opted from ancient cellular mechanisms. We propose that studying antibacterial responses across diverse eukaryotes can reveal novel modes of defense, while highlighting the critical innovations that occurred early in the evolution of our own immune systems.
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