ProfCom: a web tool for profiling the complex functionality of gene groups identified from high-throughput data.

ProfCom: a web tool for profiling the complex functionality of gene groups identified from high-throughput data.
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Profcom:用于分析从高通量数据识别的基因组复杂功能的Web工具。

DOI:
10.1093/nar/gkn239
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发表时间:
2008-07-01
影响因子:
14.9
通讯作者:
Mewes, Hans W.
Mewes, Hans W.
中科院分区:
生物学2区
文献类型:
--
作者:
Antonov, Alexey V.;Schmidt, Thorsten;Wang, Yu;Mewes, Hans W.

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ProfCom是一个基于网络的工具,用于对通过实验确定为相关的基因列表进行功能解释。一个特点,使ProfCom一个独特的工具是一个配置文件丰富的能力,不仅可用的基因本体论(GO)的条款,但也“复杂的功能”。“复函数”被构造为可用GO项的布尔组合。ProfCom推断的复杂功能比单个术语更具体,更准确地描述了基因的功能作用。ProfCom提供了一个用户友好的对话框驱动的网页提交几个模式生物,并支持大多数可用的基因标识符。此外,Web服务接口允许提交任何类型的注释数据。ProfCom可在http://webclu.bio.wzw.tum.de/profcom/免费获得。
ProfCom is a web-based tool for the functional interpretation of a gene list that was identified to be related by experiments. A trait which makes ProfCom a unique tool is an ability to profile enrichments of not only available Gene Ontology (GO) terms but also of ‘complex functions’. A ‘Complex function’ is constructed as Boolean combination of available GO terms. The complex functions inferred by ProfCom are more specific in comparison to single terms and describe more accurately the functional role of genes. ProfCom provides a user friendly dialog-driven web page submission available for several model organisms and supports most available gene identifiers. In addition, the web service interface allows the submission of any kind of annotation data. ProfCom is freely available at http://webclu.bio.wzw.tum.de/profcom/.
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发表时间: 2007-07
影响因子: 14.9
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