Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian, China.
Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian, China.
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DOI：
10.1186/1471-2407-6-287
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发表时间：
2006-12-15
期刊：
影响因子：
3.8
通讯作者：
Wang JS
中科院分区：
文献类型：
--
作者：
Wang Z;Tang L;Sun G;Tang Y;Xie Y;Wang S;Hu X;Gao W;Cox SB;Wang JS
持续暴露于各种环境致癌物和外源代谢酶（XME）的遗传多态性与许多类型的人类癌症有关，包括食管鳞状细胞癌（ESCC）。中国淮安是ESCC的流行地区之一，但对该地区ESCC危险因素的研究较少。本研究的目的是评估人口统计学参数、环境和食源性致癌物暴露以及XME多态性在中国淮安地区ESCC形成中的病因学作用，并探讨可能与ESCC相关的基因-基因和基因-环境相互作用。对淮安市5个乡镇的107例ESCC新诊断病例和107例居住年龄、性别匹配的对照进行了人群病例对照研究。除了定期流行病学和食物频率问卷分析外，还利用PCR技术从基因组DNA中评估了I期酶CYP1A1、CYP1B1、CYP2A6和CYP2E1以及II期酶GSTM1、GSTT1、GSTP1和染色体环氧化物水解酶（EPHX）的遗传多态性。食用辛辣食物、肥肉、发霉食物、盐渍蔬菜、进食速度快、性格内向、被动吸烟、有癌症家族史、食道病变、幽门螺杆菌感染是ESCC的显著危险因素（P < 0.05）。定期清理食品储存器具、饮用绿茶和戒酒是ESCC的保护因素（P < 0.01）。GSTT1零基因型在病例中的发生率（59.4%）高于对照组（47.2%），优势比（OR）为1.68,95%可信区间（CI）为0.96 ~ 2.97 (P = 0.07)，尤其是在男性中（OR = 2.78, 95% CI = 1.22 ~ 6.25, P = 0.01）。CYP1A1、CYP1B1、CYP2A6、CYP2E1、GSTM1、GSTP1和EPHX的多态性与ESCC无相关性（P < 0.05）。研究结果表明，饮食和环境暴露、一些人口统计学参数和GSTT1基因多态性可能在淮安地区ESCC的发生发展中起重要作用。
Continuous exposure to various environmental carcinogens and genetic polymorphisms of xenobiotic-metabolizing enzymes (XME) are associated with many types of human cancers, including esophageal squamous cell carcinoma (ESCC). Huaian, China, is one of the endemic regions of ESCC, but fewer studies have been done in characterizing the risk factors of ESCC in this area. The aims of this study is to evaluate the etiological roles of demographic parameters, environmental and food-borne carcinogens exposure, and XME polymorphisms in formation of ESCC, and to investigate possible gene-gene and gene-environment interactions associated with ESCC in Huaian, China. A population based case-control study was conducted in 107 ESCC newly diagnosed cases and 107 residency- age-, and sex-matched controls in 5 townships of Huaian. In addition to regular epidemiological and food frequency questionnaire analyses, genetic polymorphisms of phase I enzymes CYP1A1, CYP1B1, CYP2A6, and CYP2E1, and phase II enzymes GSTM1, GSTT1, GSTP1, and microsomal epoxide hydrolase (EPHX) were assessed from genomic DNA using PCR based techniques. Consuming acrid food, fatty meat, moldy food, salted and pickled vegetables, eating fast, introverted personality, passive smoking, a family history of cancer, esophageal lesion, and infection with Helicobacter pylori were significant risk factors for ESCC (P < 0.05). Regular clean up of food storage utensils, green tea consumption, and alcohol abstinence were protective factors for ESCC (P < 0.01). The frequency of the GSTT1 null genotype was higher in cases (59.4%) compared to controls (47.2%) with an odds ratio (OR) of 1.68 and 95% confidence interval (CI) from 0.96 to 2.97 (P = 0.07), especially in males (OR = 2.78; 95% CI = 1.22–6.25; P = 0.01). No associations were found between polymorphisms of CYP1A1, CYP1B1, CYP2A6, CYP2E1, GSTM1, GSTP1, and EPHX and ESCC (P > 0.05). Our results demonstrated that dietary and environmental exposures, some demographic parameters and genetic polymorphism of GSTT1 may play important roles in the development of ESCC in Huaian area, China.
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影响因子：
2.3
作者：
Abnet, CC;Borkowf, CB;Dawsey, SM
通讯作者：
Dawsey, SM
影响因子：
6.4
作者：
Johnson, KC
通讯作者：
Johnson, KC
影响因子：
6.6
作者：
Fujiki, H
通讯作者：
Fujiki, H
影响因子：
9.7
作者：
Gao, CM;Takezaki, T;Tajima, K
通讯作者：
Tajima, K
DOI：
10.1111/j.1349-7006.1999.tb00791.x
发表时间：
1999-06
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Gao CM;Takezaki T;Ding JH;Li MS;Tajima K
通讯作者：
Tajima K