Factors based on optical coherence tomography correlated with vision impairment in diabetic patients.
Factors based on optical coherence tomography correlated with vision impairment in diabetic patients.
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基于光学相干断层扫描的糖尿病患者视力损害相关因素分析。
DOI：
10.1038/s41598-021-82334-w
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发表时间：
2021-02-04
影响因子：
4.6
通讯作者：
Kase M
中科院分区：
文献类型：
--
作者：
Endo H;Kase S;Tanaka H;Takahashi M;Katsuta S;Suzuki Y;Fujii M;Ishida S;Kase M
本研究的目的是使用光学相干断层扫描（OCT）和OCT血管造影（OCTA）评估糖尿病患者视网膜结构和视力之间的关系。这项研究是在日本的一个医疗中心进行的回顾性观察研究。使用谱域 OCT 分析视网膜图像的评估。视网膜中央厚度、视网膜内层解体长度（DRIL）、内层高反射灶数量、外层高反射灶数量、视网膜内液高度、视网膜下液高度、外界膜破坏长度、外椭球区（EZ）破坏长度、浅毛细血管丛（SCP）血管密度、黄斑中心凹无血管区12个因素 (FAZ) 面积和 FAZ 圆度根据 OCT/OCTA 结果进行分析。使用多变量分析来研究基于 OCT 的因素，这些因素可能与未接受治疗的糖尿病眼视力不佳相关。共有 123 名 2 型糖尿病患者（平均年龄 61.9±12.3 岁，66 名男性和 57 名女性）的 183 只眼睛和 55 名对照受试者（平均年龄 64.4±12.5 岁，15 名男性和 40 名女性）的 62 只眼睛参加了这项研究。多元回归分析显示，基于OCT的与视力相关的因素是DRIL长度（β = 0.24，P < 0.01）、EZ破坏长度（β = 0.35，P < 0.001）和FAZ圆度（β = − 0.14， P < 0.05）。其他因素均无显着相关性。总之，DRIL 长度、EZ 破坏长度和 OCT 测量的 FAZ 圆度被确定为初治糖尿病眼视力障碍的相关因素。
The aim of this study is to evaluate the relationship between retinal structures and visual acuity in diabetic patients using optical coherence tomography (OCT) and OCT angiography (OCTA). This study was a retrospective observational study conducted at a single medical center in Japan. Evaluation of retinal images was analyzed using spectral domain OCT. Twelve factors including central retinal thickness, length of disorganization of retinal inner layer (DRIL), number of inner hyperreflective foci, number of outer hyperreflective foci, height of intraretinal fluid, height of subretinal fluid, length of external limiting membrane disruption, length of external ellipsoid zone (EZ) disruption, vessel density of superficial capillary plexus (SCP), foveal avascular zone (FAZ) area, and FAZ circularity were analyzed based on OCT/OCTA findings. Multivariate analysis was used to investigate the OCT-based factors that could be correlated with poor visual acuity in treatment-naïve diabetic eyes. A total of 183 eyes of 123 diabetic patients with type 2 diabetes (mean age 61.9 ± 12.3 years, 66 men and 57 women) and 62 eyes of 55 control subjects (mean age 64.4 ± 12.5 years, 15 men and 40 women) was enrolled in this study. Multiple regression analysis showed that OCT-based factors correlated with visual acuity were length of DRIL (β = 0.24, P < 0.01), length of EZ disruption (β = 0.35, P < 0.001), and FAZ circularity (β = − 0.14, P < 0.05). The other factors showed no significant correlation. In conclusion, the length of DRIL, length of EZ disruption, and FAZ circularity measured by OCT were identified as related factors for visual impairment in treatment-naïve diabetic eyes.
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影响因子：
5.9
作者：
Kusuhara S;Fukushima Y;Ogura S;Inoue N;Uemura A
通讯作者：
Uemura A
影响因子：
1
作者：
Anegondi, Neha;Kshirsagar, Arpita;Roy, Abhijit Sinha
通讯作者：
Roy, Abhijit Sinha
影响因子：
5.1
作者：
Ogurtsova, K.;Fernandes, J. D. da Rocha;Makaroff, L. E.
通讯作者：
Makaroff, L. E.
DOI：
10.1007/s00417-015-3143-7
发表时间：
2016-05-01
影响因子：
2.7
作者：
Di, Gong;Yu Weihong;Dong Fangtian
通讯作者：
Dong Fangtian
影响因子：
13.7
作者：
Balaratnasingam, Chandrakumar;Inoue, Maiko;Freund, K. Bailey
通讯作者：
Freund, K. Bailey