Effects of Fish Oil on HIV-Related Inflammation and Markers of Immunosenescence: A Randomized Clinical Trial.
Effects of Fish Oil on HIV-Related Inflammation and Markers of Immunosenescence: A Randomized Clinical Trial.
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DOI：
10.1089/acm.2017.0222
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Rosdil A
中科院分区：
文献类型：
--
作者：
Swanson B;Keithley J;Baum L;Leurgans S;Adeyemi O;Barnes LL;Mata M;Rosdil A
目的：探讨鱼油调节HIV感染老年人炎症和免疫衰老参数的安全性和疗效。设计：本研究采用随机、对照、双盲临床试验。设置：本研究在美国中西部一个大城市的HIV/AIDS门诊进行。受试者：共有37名年龄在40至70岁之间的临床稳定的HIV感染成年人参加了研究。干预措施：鱼油1.6 g/天给药12周或安慰剂。结果测量：测量炎症细胞因子的产生、免疫衰老的表面标志物和不良事件。结果如下：补充12周后，治疗组和对照组之间在CD 4+和CD 8 + T淋巴细胞的炎症或免疫衰老的任何指标上均无显著差异。与对照组相比，治疗组中更多的参与者报告了不良胃肠道事件。结论：1.6克/天鱼油的12周补充方案并没有有利地调节HIV感染成年人的炎症或免疫衰老参数。未来的研究应该测试直接靶向HIV相关炎症机制的药物，以确定减少炎症是否可以逆转免疫衰老。
Objective: To explore the safety and efficacy of fish oil to modulate parameters of inflammation and immunosenescence in HIV-infected older adults. Design: This study uses a randomized, controlled, double-blind clinical trial. Setting: The study was conducted in an outpatient HIV/AIDS clinic in a large urban Midwestern city in the United States. Subjects: A total of 37 clinically stable HIV-infected adults between the ages of 40 and 70 years of age participated. Interventions: Fish oil 1.6 g/day was administered for 12 weeks or placebo. Outcome measures: Inflammatory cytokine production, surface markers of immunosenescence, and adverse events were measured. Results: After 12 weeks of supplementation, there were no significant differences between the treatment and control groups on any measures of inflammation or immunosenescence in both CD4+ and CD8+ T lymphocytes. More participants in the treatment group reported adverse gastrointestinal events compared with the control group. Conclusions: A 12-week supplementation regimen of 1.6 g/day of fish oil did not favorably modulate parameters of inflammation or immune senescence in HIV-infected adults. Future studies should test agents that directly target mechanisms that underlie HIV-related inflammation to determine whether reducing inflammation can reverse immunosenescence.
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DOI：
10.1038/nri3405
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