Individual differences in the relationship between episodic detail generation and resting state functional connectivity vary with age.
Individual differences in the relationship between episodic detail generation and resting state functional connectivity vary with age.
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情景细节生成与静息状态功能连通性之间关系的个体差异因年龄而异。
DOI：
10.1016/j.neuropsychologia.2021.108138
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发表时间：
2022-02-10
期刊：
影响因子：
2.6
通讯作者：
Grilli MD
中科院分区：
文献类型：
--
作者：
Matijevic S;Andrews-Hanna JR;Wank AA;Ryan L;Grilli MD
在回忆自传体事件时产生情节细节的能力被认为取决于形成后内侧网络（PMN）的一组大脑区域。然而，情节细节产生的年龄相关差异与PMN的关系仍不清楚。本研究试图检验个体差异以及年龄在PMN静息态功能连接（rsFC）与情节细节产生的关联中所起的作用。中老年和老年成年人（N = 41，年龄52 - 81岁）以及年轻成年人（N = 21，年龄19 - 35岁）被要求描述近期的个人事件，并且这些记忆叙述按照情节、语义和“其他”细节进行编码。独立成分分析和感兴趣区域分析被用于分别评估PMN内前连接（海马体和内侧前额叶）和后连接（海马体、海马旁回和顶枕叶）的rsFC，因为这些连接据称在情节细节产生中具有不同的功能作用。与年轻成年人相比，老年成年人产生的记忆叙述具有较低的情节特异性（情节细节与总细节的比率）以及更多的语义细节。在老年成年人中，情节细节数量和情节特异性随着年龄的增长而降低。PMN的rsFC没有显著的年龄差异。在老年组中，更强的前PMN rsFC与较低的情节细节相关，但在年轻组中并非如此。在老年成年人中，年龄的增长导致前PMN rsFC增加与情节特异性降低之间存在关联。相反，年龄的增长导致后PMN rsFC增加与语义细节增加之间存在关联。本研究提供的证据表明，PMN内的功能连接，特别是前PMN，追踪老年成年人所提取的情节细节数量的个体差异。此外，这些脑 - 行为关系似乎具有年龄特异性，这表明衰老过程中的某些变化改变了前PMN rsFC和情节细节相互关联的性质。这个过程是否涉及PMN完整性的年龄相关丧失，或者是向语义提取的年龄相关转变，还有待确定。
The ability to generate episodic details while recollecting autobiographical events is believed to depend on a collection of brain regions that form a posterior medial network (PMN). How age-related differences in episodic detail generation relate to the PMN, however, remains unclear. The present study sought to examine individual differences, and the role of age, in PMN resting state functional connectivity (rsFC) associations with episodic detail generation. Late middle-aged and older adults (N = 41, ages 52–81), and young adults (N = 21, ages 19–35) were asked to describe recent personal events, and these memory narratives were coded for episodic, semantic and ‘miscellaneous’ details. Independent components analysis and regions-of-interest analyses were used to assess rsFC within the PMN separately for anterior connections (hippocampal and medial prefrontal) and posterior connections (hippocampal, parahippocampal and parieto-occipital), as these connections purportedly serve different functional roles in episodic detail generation. Compared to younger adults, older adults produced memory narratives with lower episodic specificity (ratio of episodic:total details) and a greater amount of semantic detail. Among the older adults, episodic detail amounts and episodic specificity were reduced with increasing age. There were no significant age differences in PMN rsFC. Stronger anterior PMN rsFC was related to lower episodic detail in the older adult group, but not in the young. Among the older adults, increasing age brought on an association between increased anterior PMN rsFC and reduced episodic specificity. In contrast, increasing age brought on an association between increased posterior PMN rsFC and increased semantic detail. The present study provides evidence that functional connectivity within the PMN, particularly anterior PMN, tracks individual differences in the amount of episodic details retrieved by older adults. Furthermore, these brain-behavior relationships appear to be age-specific, indicating that some process within aging alters the nature of how anterior PMN rsFC and episodic detail relate to each other. Whether this process entails an age-related loss of integrity to the PMN, or an age-related shift toward semantic retrieval, remains to be determined.
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影响因子：
3.5
作者：
Abraham A;Pedregosa F;Eickenberg M;Gervais P;Mueller A;Kossaifi J;Gramfort A;Thirion B;Varoquaux G
通讯作者：
Varoquaux G
DOI：
10.1523/jneurosci.1239-18.2018
发表时间：
2018-12-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bonnici HM;Cheke LG;Green DAE;FitzGerald THMB;Simons JS
通讯作者：
Simons JS
DOI：
10.1016/j.nicl.2018.03.008
发表时间：
2018
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Ahmed S;Irish M;Loane C;Baker I;Husain M;Thompson S;Blanco-Duque C;Mackay C;Zamboni G;Foxe D;Hodges JR;Piguet O;Butler C
通讯作者：
Butler C
影响因子：
2.6
作者：
Conway, Martin A.
通讯作者：
Conway, Martin A.
影响因子：
15.9
作者：
Burke SN;Gaynor LS;Barnes CA;Bauer RM;Bizon JL;Roberson ED;Ryan L
通讯作者：
Ryan L